Search
Search Results
-
A pan-sarcoma landscape of telomeric content shows that alterations in RAD51B and GID4 are associated with higher telomeric content
Tumor cells need to activate a telomere maintenance mechanism, enabling limitless replication. The bulk of evidence supports that sarcomas...
-
Telomeric retrotransposons show propensity to form G-quadruplexes in various eukaryotic species
BackgroundCanonical telomeres (telomerase-synthetised) are readily forming G-quadruplexes (G4) on the G-rich strand. However, there are examples of...
-
The State of the LPO—AOD System and the Relative Length of Telomeric Repeats in the Chromosomes of Blood Leukocytes in Obstructive Sleep Apnea Syndrome
We analyzed the relative length of telomeric repeats in peripheral blood leukocytes and indicators of oxidative stress in 32 men (mean age 51.2±3.1...
-
The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements
Single-molecule analysis has emerged as a powerful biophysical technique, allowing the investigation of molecular interactions at unprecedented...
-
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data
ObjectiveTo assess the genetic and epigenetic effects promoted by Bisphenol A (BPA) exposure in adolescent males from the Spanish INMA-Granada birth...
-
A pan-cancer landscape of telomeric content shows that RAD21 and HGF alterations are associated with longer telomeres
BackgroundCancer cells can proliferate indefinitely through telomere maintenance mechanisms. These mechanisms include telomerase-dependent...
-
R-LOOPs on Short Tandem Repeat Expansion Disorders in Neurodegenerative Diseases
Expansions of short tandem repeats (STRs) have been found to be present in more than 50 diseases and have a close connection with neurodegenerative...
-
RepEnTools: an automated repeat enrichment analysis package for ChIP-seq data reveals hUHRF1 Tandem-Tudor domain enrichment in young repeats
BackgroundRepeat elements (REs) play important roles for cell function in health and disease. However, RE enrichment analysis in short-read...
-
TERRA G-quadruplex stabilization as a new therapeutic strategy for multiple myeloma
BackgroundMultiple myeloma (MM) is a hematologic malignancy characterized by high genomic instability, and telomere dysfunction is an important cause...
-
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells
Telomere repeat binding factor 2 (TRF2), a critical element of the shelterin complex, plays a vital role in the maintenance of genome integrity. TRF2...
-
RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function
RBL2/p130, a member of the retinoblastoma family of proteins, is a key regulator of cell division and propagates irreversible senescence. RBL2/p130...
-
Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia
BackgroundRepeat elements constitute a large proportion of the human genome and recent evidence indicates that repeat element expression has...
-
The S100A7 nuclear interactors in autoimmune diseases: a coevolutionary study in mammals
S100A7, a member of the S100A family of Ca 2+ -binding proteins, is considered a key effector in immune response. In particular, S100A7 dysregulation...
-
Giardia telomeres and telomerase
Giardia duodenalis , the protozoan responsible for giardiasis, is a significant contributor to millions of diarrheal diseases worldwide. Despite the...
-
A complete telomere-to-telomere assembly of the maize genome
A complete telomere-to-telomere (T2T) finished genome has been the long pursuit of genomic research. Through generating deep coverage ultralong...
-
Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting
BackgroundRecurrence and distant metastasis are still the main factors leading to treatment failure for malignant tumors including nasopharyngeal...
-
Loss of SUN1 function in spermatocytes disrupts the attachment of telomeres to the nuclear envelope and contributes to non-obstructive azoospermia in humans
One of the most severe forms of infertility in humans, caused by gametogenic failure, is non-obstructive azoospermia (NOA). Approximately, 20–30% of...
-
Telomerase and its Inhibitor in Cancer Therapeutics: Current Status and Future Prospective
Telomerase is an extremely specific reverse transcriptase (RT) that involves maintaining telomeric length by duplicating TTAGGG nucleotide DNA...
-
Genetic Assays to Study Repeat Fragility in Saccharomyces cerevisiae
Trinucleotide repeats are common in the human genome and can undergo changes in repeat number and cause length-dependent chromosome fragility....
-
DNA methylation profiles in individuals with rare, atypical 7q11.23 CNVs correlate with GTF2I and GTF2IRD1 copy number
Williams-Beuren syndrome (WBS) and 7q11.23 duplication syndrome (Dup7) are rare neurodevelopmental disorders caused by deletion and duplication of a...
