Search
Search Results
-
Single nucleotide polymorphisms to predict taxanes toxicities and effectiveness in cancer patients
Taxanes are used in the treatment of several solid tumours. Adverse events (AEs) might be influenced by single nucleotide polymorphisms (SNPs) in...
-
A biomarker of aging, p16, predicts peripheral neuropathy in women receiving adjuvant taxanes for breast cancer
Identifying patients at higher risk of chemotherapy-induced peripheral neuropathy (CIPN) is a major unmet need given its high incidence, persistence,...
-
Comparison between nab-paclitaxel and solvent-based taxanes as neoadjuvant therapy in breast cancer: a systematic review and meta-analysis
BackgroundTo compare the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and solvent-based taxanes (sb-taxanes) as...
-
Tunable polymeric micelles for taxane and corticosteroid co-delivery
Nanomedicine holds promise for potentiating drug combination therapies. Increasing (pre)clinical evidence is available exemplifying the value of...
-
Obstetric and neonatal outcomes following taxane use during pregnancy: a systematic review
BackgroundThe use of taxanes following the first trimester of pregnancy is endorsed by current clinical guidelines. However, evidence regarding their...
-
Phase 2 study of cabazitaxel as second-line treatment in patients with HER2-negative metastatic breast cancer previously treated with taxanes—a Hellenic Cooperative Oncology Group (HeCOG) Trial
BackgroundCabazitaxel is a novel taxane that might be active in breast cancer resistant to first-generation taxanes.
MethodsThe purpose of the...
-
GRP78 expression in peripheral blood mononuclear cells is a new predictive marker for the benefit of taxanes in breast cancer neoadjuvant treatment
BackgroundBreast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy...
-
TRF2 as novel marker of tumor response to taxane-based therapy: from mechanistic insight to clinical implication
BackgroundBreast Cancer (BC) can be classified, due to its heterogeneity, into multiple subtypes that differ for prognosis and clinical management....
-
Key genes and molecular mechanisms related to Paclitaxel Resistance
Paclitaxel is commonly used to treat breast, ovarian, lung, esophageal, gastric, pancreatic cancer, and neck cancer cells. Cancer recurrence is...
-
Long-term survival after neoadjuvant therapy for triple-negative breast cancer under different treatment regimens: a systematic review and network meta-analysis
BackgroundTriple-negative breast cancer (TNBC) is a life-threatening subtype of breast cancer with limited treatment options. Therefore, this network...
-
Efficacy of different neoadjuvant treatment regimens in BRCA-mutated triple negative breast cancer: a systematic review and meta-analysis
PurposeTriple negative breast cancer (TNBC) is an aggressive breast cancer strongly associated with BRCA mutation. Standard neoadjuvant chemotherapy...
-
A Study on the Role of Phytochemicals in the Preclinical Neuronal Cancer Model
With more research being conducted to elucidate the various molecular mechanism of cancer progression, the development of chemically synthesized...
-
“Moderate” adjuvant chemotherapy-induced leukopenia is beneficial for survival of patients with early breast cancer: a retrospective study
BackgroundThe association between chemotherapy-induced leukopenia (CIL) and survival for patients with early breast cancer (EBC) is not known. We...
-
Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells
Ovarian cancer is one of the most common gynecologic malignancies in women and has a poor prognosis. Taxanes are a class of standard first-line...
-
Process evaluation protocol plan for a home-based physical activity intervention versus educational intervention for persistent taxane-induced peripheral neuropathy (B-HAPI study): a randomized controlled trial
BackgroundEvaluation publications typically summarize the results of studies to demonstrate the effectiveness of an intervention, but little is...
-
Survival benefit of platinum-based regimen in early stage triple negative breast cancer: A meta-analysis of randomized controlled trials
Platinum (Pt)-based chemo-regimens have been proved effective in neoadjuvant and salvage chemotherapy of triple negative breast cancer (TNBC)....
-
A Study on the Role of Phytochemicals in the Preclinical Neuronal Cancer Model
With more research being conducted to elucidate the various molecular mechanism of cancer progression, the development of chemically synthesized...
-
Dose-dense sequential adjuvant chemotherapy in the trastuzumab era: final long-term results of the Hellenic Cooperative Oncology Group Phase III HE10/05 Trial
BackgroundDose-dense sequential chemotherapy with anthracyclines and taxanes achieved an 18% reduction of recurrence risk in early breast cancer...
-
Therapeutic Options in BRCA1-Linked Breast Cancer and Systemic Approaches
BReast CAncer gene 1 (BRCA1) has been established as a regulator of DNA repair, cell cycle, and transcription in response to any damage to DNA....
-
Sequencing of genes of drug response in tumor DNA and implications for precision medicine in cancer patients
Tumor DNA sequencing is becoming standard-of-care for patient treatment decisions. We evaluated genotype concordance between tumor DNA and genomic...
