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Palmitic Acid Induces Posttranslational Modifications of Tau Protein in Alzheimer’s Disease–Related Epitopes and Increases Intraneuronal Tau Levels
Metabolic diseases derived from an unhealthy lifestyle have been linked with an increased risk for develo** cognitive impairment and even...
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All-Trans Retinoic Acid-Induced Cell Surface Heat Shock Protein 90 Mediates Tau Protein Internalization and Degradation in Human Microglia
This study investigates the role of all-trans retinoic acid (ATRA) in modulating the expression of heat shock protein 90 (Hsp90) and its influence on...
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Spreading of Tau Protein Does Not Depend on Aggregation Propensity
The stereotypical progression of Tau pathology during Alzheimer disease has been attributed to trans-neuronal spreading of misfolded Tau proteins,...
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Comparison of Neuroinflammation Induced by Hyperphosphorylated Tau Protein Versus Ab42 in Alzheimer’s Disease
Both neurofibrillary tangles and senile plaques are associated with inflammation in Alzheimer’s disease (AD). Their relative degree of induced...
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Role of curcumin on beta-amyloid protein, tau protein, and biochemical and oxidative changes in streptozotocin-induced diabetic rats
Diabetes is one of the most common endocrine metabolic diseases and is associated with the accumulation of beta-amyloid plaques in the brain. Amyloid...
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Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats
ObjectiveAnesthetics have been linked to cognitive alterations, particularly in the elderly. The current research delineates how Fibroblast Growth...
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A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization
BackgroundSoluble oligomeric forms of Tau protein have emerged as crucial players in the propagation of Tau pathology in Alzheimer’s disease (AD)....
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Toxic Tau Aggregation in AD
Alzheimer’s disease (AD) is a neurodegenerative disorder that is caused by multiple factors, has a complicated physiopathology, and the causes of its...
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Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau
Tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as Alzheimer’s disease....
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Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease
BackgroundNovel phosphorylated-tau (p-tau) blood biomarkers (e.g., p-tau181, p-tau217 or p-tau231), are highly specific for Alzheimer’s disease (AD),...
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Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
BackgroundProgression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumulation of protein...
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Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
BackgroundAutosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhancing protein...
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Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice
Tau oligomers play critical roles in tau pathology and are responsible for neuronal cell death and transmitting the disease in the brain....
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Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice
Accumulation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau is a histopathological hallmark of Alzheimer’s disease (AD) and...
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Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous...
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Nuclear face of Tau: an inside player in neurodegeneration
Tau (Tubulin associated unit) protein is a major hallmark of Alzheimer’s disease (AD) and tauopathies. Tau is predominantly an axonal protein with a...
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Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain
Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would therefore be ideal biomarkers for clinical trials...
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Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau...
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Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development
Nuclear inhibitor of protein phosphatase 1 (NIPP1) is a known regulator of gene expression and plays roles in many physiological or pathological...
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The Role of Post-Translational Modifications on the Structure and Function of Tau Protein
Involving addition of chemical groups or protein units to specific residues of the target protein, post-translational modifications (PTMs) alter the...
