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Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
BackgroundTau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimer’s disease, frontotemporal lobar degeneration...
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Toxic Tau Aggregation in AD
Alzheimer’s disease (AD) is a neurodegenerative disorder that is caused by multiple factors, has a complicated physiopathology, and the causes of its...
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Passive immunotherapy for Alzheimer’s disease: challenges & future directions
Passive immunotherapy with specific antibodies targeting Amyloid β (Aβ) peptide or tubulin-associated unit (tau) protein has emerged as a promising...
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Immunotherapy and Pain
Immunotherapy was initially developed as a method to treat cancer through the use of the host’s immune system. Now, immunotherapy is used as a...
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Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer’s disease
The use of biomarker-led clinical trial designs has been transformative for investigating amyloid-targeting therapies for Alzheimer’s disease (AD)....
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Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation
Alzheimer’s Disease (AD) contributes to most cases of dementia. Its prominent neuropathological features are the extracellular neuritic plaques and...
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Tau Pathology in Neurodegenerative Diseases
Aggregation and cellular accumulation of tau protein is a defining feature of tauopathies, a class of histopathologically and clinically...
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Exploring the Role of Tau Proteins in Alzheimer’s Disease from Typical Functioning MAPs to Aberrant Fibrillary Deposits in the Brain
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that leads to memory loss and cognitive function deficits in affected...
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Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features, including...
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Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine
Abnormal phosphorylation of the microtubule-binding protein tau in the brain is a key pathological marker for Alzheimer’s disease and additional...
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Spinal Cord Injury Causes Prominent Tau Pathology Associated with Brain Post-Injury Sequela
Spinal cord injury (SCI) can result in significant neurological impairment and functional and cognitive deficits. It is well established that SCI...
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Immunotherapy for Alzheimer’s disease: targeting β-amyloid and beyond
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly worldwide. However, the complexity of AD pathogenesis leads to...
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In the Slip Stream of Amyloid: The Tau and Tangle Hypothesis
Tangles are prominent abnormalities in the postmortem brain tissue of Alzheimer’s but, just as amyloid beta peptide, also present in the normal...
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Role of Tau in Various Tauopathies, Treatment Approaches, and Emerging Role of Nanotechnology in Neurodegenerative Disorders
A few protein kinases and phosphatases regulate tau protein phosphorylation and an imbalance in their enzyme activity results in tau...
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“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
Phosphorylation is one of the most prevalent post-translational modifications found in aggregated tau isolated from Alzheimer’s disease (AD) patient...
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Immunogenicity of MultiTEP platform technology-based Tau vaccine in non-human primates
Pathological forms of Tau protein are directly associated with neurodegeneration and correlate with Alzheimer’s Disease (AD) symptoms, progression,...
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Tau Toxicity in Neurodegeneration
Tau is a microtubule-associated protein widely distributed in the central nervous system (CNS). The main function of tau is to promote the assembly...
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Plasma phospho-tau in Alzheimer’s disease: towards diagnostic and therapeutic trial applications
As the leading cause of dementia, Alzheimer's disease (AD) is a major burden on affected individuals, their families and caregivers, and healthcare...
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Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
BackgroundAlzheimer’s disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau...
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Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice
One of the main pathological hallmarks of Alzheimer’s disease (AD) is the intraneuronal accumulation of hyperphosphorylated tau. Passive...
