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Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways
Recent genetic studies have identified variants associated with bipolar disorder (BD), but it remains unclear how brain gene expression is altered in...
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Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling
γ-Aminobutyric acid B receptors (GABABRs) are broadly expressed throughout the central nervous system where they play an important role in regulating...
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Cardiac and neuronal HCN channelopathies
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four different isoforms (HCN1-4) in the heart and in the central...
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Identifying molecular mediators of environmentally enhanced neurogenesis
Adult hippocampal neurogenesis occurs throughout life and supports healthy brain functions. The production of new neurons decreases with age, and...
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PDZ Scaffold Protein CAL Couples with Metabotropic Glutamate Receptor 5 to Protect Against Cell Apoptosis and Is a Potential Target in the Treatment of Parkinson’s Disease
Targeting mGluR5 has been an attractive strategy to modulate glutamate excitotoxicity for neuroprotection. Although human clinical trials using...
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Interferon-β Inhibits Neurotrophin 3 Signalling and Pro-Survival Activity by Upregulating the Expression of Truncated TrkC-T1 Receptor
Although clinically useful for the treatment of various diseases, type I interferons (IFNs) have been implicated as causative factors of a number of...
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Class C GPCRs: Metabotropic Glutamate Receptors
Metabotropic Glutamate receptors (mGluRs) belong to Family C GPCRs. Interestingly enough receptors for Gamma-amino butyric acid, the GABAb receptors...
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Neurotrophin Signaling and Stem Cells—Implications for Neurodegenerative Diseases and Stem Cell Therapy
Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is mediated by the tropomyosin receptor kinase (TRK) receptor...
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Trk Receptors
The tropomyosin-related tyrosine kinase (Trk) receptors were initially described as a family of growth factor receptors required for neuronal...
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Phosphoinositides and PDZ Domain Scaffolds
The discovery that PSD-95/Discs large/ZO-1 (PDZ) domains can function as lipid-binding modules, in particular interacting with phosphoinositides...
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Diversity of Metabotropic Glutamate Receptor–Interacting Proteins and Pathophysiological Functions
In the mammalian brain, the large majority of excitatory synapses express pre- and postsynaptic glutamate receptors. These are ion channels and G...
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Molecular Mechanisms of G Protein-Independent Signaling Mediated by 7-Transmembrane Receptors
Receptors of the 7-TMR group (G protein-coupled receptors, GPCRs) are uniquely important from the fundamental physiological aspect because they...
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Exploring HCN channels as novel drug targets
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the control of heart rate and neuronal excitability. Ivabradine...
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Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin adjuvant
Earlier studies have reported on both proinflammatory and anti-inflammatory activities of cholera toxin (CT). As CT is a powerful adjuvant, we were...
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