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Biophysical Regulation of TGFβ Signaling in the Tumor Microenvironment
Transforming growth factor (TGF)-β is a multifunctional cytokine that contributes to epithelial–mesenchymal transition, tumor development, and...
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TGFβ signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
RationaleColorectal Cancer (CRC) represents the third most common type of cancer in Germany and the second most common cancer-related cause of death...
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The safety and efficacy of systemic delivery of a new liver-de-targeted TGFβ signaling inhibiting adenovirus in an immunocompetent triple negative mouse mammary tumor model
Aberrant TGFβ signaling is linked to metastasis and tumor immune escape of many cancers including metastatic triple negative breast cancer (mTNBC)....
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Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the develo** human lung
Alveolar type 2 (AT2) cells function as stem cells in the adult lung and aid in repair after injury. The current study aimed to understand the...
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LncRNA-Gm9866 promotes liver fibrosis by activating TGFβ/Smad signaling via targeting Fam98b
ObjectiveThe exact mechanism and target molecules of liver fibrosis have remained largely elusive. Here, we investigated the role of long noncoding...
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TGFβ carrying exosomes in plasma: potential biomarkers of cancer progression in patients with head and neck squamous cell carcinoma
ObjectivesContributions of TGFβ to cancer progression are well documented. However, plasma TGFβ levels often do not correlate with...
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Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma
BackgroundPoor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a...
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TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective
The immune system responds to cancer in two main ways. First, there are prewired responses involving myeloid cells, innate lymphocytes and...
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APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). The contribution of microglial APOE4 to AD...
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Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin
BackgroundAs in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some...
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Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing
Various therapies have been utilized for treating diabetic wounds, yet current regiments do not simultaneously address the key intrinsic causes of...
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TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence...
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Crizotinib attenuates cancer metastasis by inhibiting TGFβ signaling in non-small cell lung cancer cells
Crizotinib is a clinically approved tyrosine kinase inhibitor for the treatment of patients with locally advanced or metastatic non-small cell lung...
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Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating selected features of TGFβ inhibition
BackgroundLess than 11% of pancreatic cancer patients survive 5-years post-diagnosis. The unique biology of pancreatic cancer includes a significant...
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Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration
Recruiting endogenous stem cells to bone defects without stem cell transplantation and exogenous factor delivery represents a promising strategy for...
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Overcoming TGFβ-mediated immune evasion in cancer
Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during development and tissue homeostasis; hence, dysregulation...
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Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling
Both epidemiological and animal studies suggest that adverse environment during pregnancy can change the offspring development programming, but it is...
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The autocrine glycosylated-GREM1 interacts with TGFB1 to suppress TGFβ/BMP/SMAD-mediated EMT partially by inhibiting MYL9 transactivation in urinary carcinoma
PurposeUrothelial carcinoma (UC) is a common disease in developed counties. This study aimed to identify autocrine roles and signaling pathways of...
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TGFβ Signaling in the Tumor Microenvironment
Transforming growth factor beta (TGFβ) is a pleiotropic growth factor. Under normal physiological conditions, TGFβ maintains homeostasis in mammalian...