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Ferroptosis related gene signature in T cell-mediated rejection after kidney transplantation
BackgroundT cell-mediated rejection is an important factor affecting early transplant kidney survival. Ferroptosis has been shown to play a...
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Cell-free DNA for the detection of kidney allograft rejection
Donor-derived cell-free DNA (dd-cfDNA) is an emerging noninvasive biomarker that has the potential to detect allograft injury. The capacity of...
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Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation
Interferon-γ (IFN-γ) is an important cytokine in tissue homeostasis and immune response, while studies about it in antibody-mediated rejection (ABMR)...
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The Biology and Molecular Basis of Organ Transplant Rejection
Allograft rejection is defined as tissue injury in a transplanted allogeneic organ produced by the effector mechanisms of the adaptive alloimmune...
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Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy
BK polyomavirus-associated nephropathy (BKPyVAN) is a common cause of allograft failure. However, differentiation between BKPyVAN and type I T...
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An automated histological classification system for precision diagnostics of kidney allografts
For three decades, the international Banff classification has been the gold standard for kidney allograft rejection diagnosis, but this system has...
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B-cell activating factor BAFF as a novel alert marker for the immunological risk stratification after kidney transplantation
The B cell activating factor BAFF has gained importance in the context of kidney transplantation due to its role in B cell survival. Studies have...
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Cytotoxic T Lymphocytes (CTLs) and Kidney Transplantation: An Overview
Involvement of T lymphocytes in kidney transplantation is a well-developed topic; however, most of the scientific interest focused on the different...
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Immune-Mediated Liver Disease in the Transplanted Liver
Liver transplantation has evolved as the treatment of choice for many patients with end-stage liver disease. Currently, survival posttransplant is...
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The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation
The identity of histocompatibility loci, besides human leukocyte antigen ( HLA ), remains elusive. The major histocompatibility complex (MHC) class I MICA...
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An Updated Focus on Immune Checkpoint Inhibitors and Tubulointerstitial Nephritis
One of the most relevant achievements in oncological research is represented by the development of a new category of anticancer drugs, the immune...
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In-silico performance, validation, and modeling of the Nanostring Banff Human Organ transplant gene panel using archival data from human kidney transplants
BackgroundRNA gene expression of renal transplantation biopsies is commonly used to identify the immunological patterns of graft rejection. Mostly...
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Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas
The pathogenesis of allograft (dys)function has been increasingly studied using ‘omics’-based technologies, but the focus on individual organs has...
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Identification of Candidate Biomarkers for Transplant Rejection from Transcriptome Data: A Systematic Review
BackgroundTraditional methods for rejection control in transplanted patients are considered invasive, risky, and prone to sampling errors. Using...
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Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity
The early detection of the onset of transplant rejection is critical for the long-term survival of patients. The diagnostic gold standard for...
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How will artificial intelligence and bioinformatics change our understanding of IgA Nephropathy in the next decade?
IgA nephropathy (IgAN) is the most common glomerulonephritis. It is characterized by the deposition of immune complexes containing immunoglobulin A...
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Advances in Detection of Kidney Transplant Injury
Early detection of graft injury after kidney transplantation is key to maintaining long-term good graft function. Graft injury could be due to a...
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CYP3A5 gene polymorphisms and their impact on dosage and trough concentration of tacrolimus among kidney transplant patients: a systematic review and meta-analysis
Tacrolimus is an immunosuppressive drug widely used in kidney transplantation. Cytochrome P450 3A5 (CYP3A5) protein is involved in tacrolimus...
