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When Screening for Severe Combined Immunodeficiency (SCID) with T Cell Receptor Excision Circles Is Not SCID: a Case-Based Review
Newborn screening efforts focusing on the quantification of T cell receptor excision circles (TRECs), as a biomarker for abnormal thymic production...
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A Beginner’s Guide to T Cell Development
T lymphocytes (T cells) are essential components of the adaptive immune system; they serve multiple functions in responses to pathogens and to ensure...
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Newborn Screening for Severe T and B Cell Lymphopenia Using TREC/KREC Detection: A Large-Scale Pilot Study of 202,908 Newborns
Newborn screening (NBS) for severe inborn errors of immunity (IEI), affecting T lymphocytes, and implementing measurements of T cell receptor...
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TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2
The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human...
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The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state
The T cell repertoire of healthy mice and humans harbors self-reactive CD4 + conventional T (T conv ) cells capable of inducing autoimmunity. Using T...
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Allogeneic Hematopoietic cell Transplantation Using Alemtuzumab in Asian Patients with Inborn Errors of Immunity
Alemtuzumab is used with reduced-toxicity conditioning (RTC) in allogeneic hematopoietic cell transplantation (HCT), demonstrating efficacy and...
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Successful Immune Reconstitution in a Patient with a TYK2 Deficiency after Allogeneic Stem Cell Transplantation from Unrelated Donors
A boy with primary immunodeficiency, caused by a tyrosine kinase 2 ( TYK2 ) mutation, presented with immune defects and a lifelong history of severe...
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18q Deletion Syndrome Presenting with Late-Onset Combined Immunodeficiency
Patients with chromosome 18q deletion syndrome generally experience hypogammaglobulinemia. Herein, we describe two patients with chromosome 18q...
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Dynamics of thymus function and T cell receptor repertoire breadth in health and disease
T cell recognition of unknown antigens relies on the tremendous diversity of the T cell receptor (TCR) repertoire; generation of which can only occur...
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Determining the Number of TREC and KREC Copies for Screening of Inborn Errors of Immunity
T-cell receptor excision circles (TRECs) and kappa-deleting recombinant excision circles (KRECs) are circular DNA molecules that are formed in the...
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Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population
BackgroundFatty degeneration of thymus (or thymus involution) has long been considered a normal ageing process. However, there is emerging evidence...
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The role of the thymus in allogeneic bone marrow transplantation and the recovery of the peripheral T-cell compartment
As the thymus represents the primary site of T-cell development, optimal thymic function is of paramount importance for the successful reconstitution...
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Generation of CAR-T Cells with Slee** Beauty Transposon Gene Transfer
Human T lymphocytes that transgenically express a chimeric antigen receptor (CAR)Chimeric antigen receptor (CAR) have proven efficacy and safety in...
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Modelling Naive T Cell Homeostasis
The need to maintain cell populations at near-constant sizes – that is, to maintain homeostasis – is ubiquitous in living organisms. Cell populations...
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A Novel RAC2 Mutation Causing Combined Immunodeficiency
PurposeRas-related C3 botulinum toxin substrate 2 (RAC2) acts as a molecular switch and has crucial roles in cell signaling and actin dynamics. A...
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Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
The intestinal immune system interacts with commensal microbiota to maintain gut homeostasis. Furthermore, stress alters the microbiome composition,...
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Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship
Childhood acute lymphoblastic leukemia (cALL) survivors suffer early-onset chronic diseases classically associated with aging. Normal aging is...
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Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients
PurposeCD40 ligand (CD40L)-deficient patients display increased susceptibilities to infections that can be mitigated with effective prophylactic...
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Thymic function and survival at advance ages in nursing home residents from Southern Italy
BackgroundImmunosenescence is a complex process characterized by an age-related remodelling of immune system. The prominent effects of the...
