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A Simple Approach to Preparation of Surfactant Nano-Micelles Loaded Drugs
The ability to formulate optimum drug-loaded carriers is a challenge that impedes virtuous drug delivery and stability. Nano micelles (NMs) are...
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Optimization of Lung Surfactant Coating of siRNA Polyplexes for Pulmonary Delivery
PurposeThe aim of this study was to understand how coating with a pulmonary surfactant, namely Alveofact, affects the physicochemical parameters as...
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The Opportunity of Surfactant Protein D as a Potential Biomarker for Detecting Acute Lung Injury
Acute lung injury is a medical problem that causes a high mortality rate if it is not detected early and followed by appropriate treatment. The...
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Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease
Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs) are frequently found under oxidative stress conditions and/or...
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Lysophosphatidylcholine Acyltransferase 1 Deficiency Promotes Pulmonary Emphysema via Apoptosis of Alveolar Epithelial Cells
Chronic obstructive pulmonary disease (COPD) is primarily caused by inhalation of cigarette smoke and is the third leading cause of death worldwide....
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Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis
BackgroundLung cancer is the leading cause of cancer-related death worldwide. We previously found that Mediator complex subunit 23 (MED23) is...
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CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia
Preterm infants with oxygen supplementation are at high risk for bronchopulmonary dysplasia (BPD), a neonatal chronic lung disease. Inflammation with...
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The Opportunity of Surfactant Protein D as a Potential Biomarker for Detecting Acute Lung Injury
Acute lung injury is a medical problem that causes a high mortality rate if it is not detected early and followed by appropriate treatment. The...
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Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden (TMB) and sensitivity to immune checkpoint blockade (ICB)...
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Effect of acid sphingomyelinase deficiency in type A Niemann-Pick disease on the transport of therapeutic nanocarriers across the blood–brain barrier
ASM deficiency in Niemann-Pick disease type A results in aberrant cellular accumulation of sphingomyelin, neuroinflammation, neurodegeneration, and...
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Pulmonary Alveolar Proteinosis and Multiple Infectious Diseases in a Child with Autosomal Recessive Complete IRF8 Deficiency
BackgroundAutosomal recessive (AR) complete IRF8 deficiency is a rare severe inborn error of immunity underlying an absence of blood myeloid...
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Surfactant Protein D: A Therapeutic Target for Allergic Airway Diseases
Surfactant protein D (SP-D), expressed in respiratory epithelium, is important for modulating both innate and adaptive immunity against inhaled...
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Primaquine Loaded Solid Lipid Nanoparticles (SLN), Nanostructured Lipid Carriers (NLC), and Nanoemulsion (NE): Effect of Lipid Matrix and Surfactant on Drug Entrapment, in vitro Release, and ex vivo Hemolysis
Primaquine (PQ), an 8-aminoquinoline antimalarial drug, has been widely used for the eradication of hypnozoites from the liver and, therefore,...
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Lung development and immune status under chronic LPS exposure in rat pups with and without CD26/DPP4 deficiency
Dipeptidyl-peptidase IV (CD26), a multifactorial integral type II protein, is expressed in the lungs during development and is involved in...
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Trafficking of newly synthesized surfactant protein B to the lamellar body in alveolar type II cells
Lung surfactant accumulates in the lamellar body (LB) via not only the secretory (anterograde) pathway but also the endocytic (retrograde) pathway....
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Performance of Low Air Volume Dry Powder Inhalers (LV-DPI) when Aerosolizing Excipient Enhanced Growth (EEG) Surfactant Powder Formulations
Efficient delivery of dry powder aerosols dispersed with low volumes of air is challenging. This study aims to develop an efficient dry powder...
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Hypomorphic pathogenic variant in SFTPB leads to adult pulmonary fibrosis
Biallelic pathogenic variants in the surfactant protein (SP)-B gene ( SFTPB ) have been associated with fatal forms of interstitial lung diseases (ILD)...
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A novel synonymous ABCA3 variant identified in a Chinese family with lethal neonatal respiratory failure
BackgroundLethal respiratory failure is primarily caused by a deficiency of pulmonary surfactant, and is the main cause of neonatal death among...
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A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence
BackgroundThe aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Additionally, a...
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Mefenamic Acid Loaded and TPGS Stabilized Mucoadhesive Nanoemulsion for the Treatment of Alzheimer’s Disease: Development, Optimization, and Brain-Targeted Delivery via Olfactory Pathway
Alzheimer’s disease (AD) is a very common disorder that affects the elderly. There are relatively few medications that can be used orally or as a...
