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Biomedicine

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Showing 1-20 of 107 results

  1. Gut Microbiota: Impact on Pharmacokinetics

    P. Zarmpi, N. Fotaki in The ADME Encyclopedia
    Reference work entry 2022

  2. High-Throughput Fluorescence Assays for Ion Channels and GPCRs

    Ca2+, Na+ and K+- permeable ion channels as well as GPCRs linked to Ca2+ release are important drug targets. Accordingly, high-throughput...
    Irina Vetter, David Carter, ... Samuel D. Robinson in Calcium Signaling
    Chapter 2020

  3. Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1

    Background

    Activation of NMDA receptors can induce iron movement into neurons by the small GTPase Dexras1 via the divalent metal transporter 1 (DMT1)....

    Rachel S. White, Anup K. Bhattacharya, ... Sangwon F. Kim in Molecular Brain
    Article Open access 14 April 2016

  4. Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs

    Ca2+ permeable ion channels and GPCRs linked to Ca2+ release are important drug targets, with modulation of Ca2+ signaling increasingly recognized as...
    Irina Vetter in Calcium Signaling
    Chapter 2012

  5. Combined effects of GSTP1 and MRP1 in melanoma drug resistance

    Glutathione-S-transferase Pi1 (GSTP1) and multidrug resistance protein 1 (MRP1) are overexpressed in melanoma, a skin cancer notoriously resistant to...

    P Depeille, P Cuq, ... L Vian in British Journal of Cancer
    Article Open access 05 July 2005

  7. Drug Interactions and Adverse Reactions

    A considerably detailed treatment of drug-drug interactions and adverse reactions has been presented above, together with older and more recent...
    in Drug Metabolism
    Chapter 2005

  8. Urinary 6β-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals

    6β-Hydroxycortisol (6β-OHF) urinary excretion has, for a long time, been considered a marker of drug induction and, more recently, of drug inhibition...

    M. M. Galteau, F. Shamsa in European Journal of Clinical Pharmacology
    Article 06 November 2003

  9. Cytochrome P450 3A and their regulation

    CYP3A isozymes collectively comprise the largest portion of the liver and small intestinal CYP protein and they are involved in the metabolism of...

    Oliver Burk, Leszek Wojnowski in Naunyn-Schmiedeberg's Archives of Pharmacology
    Article 21 October 2003

  10. Modelling Human Cytochrome P450-Substrate Interactions

    The cytochromes P450 (CYP) are extremely important and ubiquitous enzymes, being present in virtually all species studied to date and across the five...
    D. F. V. Lewis in Pharmacokinetic Challenges in Drug Discovery
    Conference paper 2002

  11. Garlic and its medicinal potential

    Garlic ( Allium sativum L.) has many accentuating medicinal properties and has been used as an effective remedy for a variety of chronic ailments...

    M. Afzal, M. Ali, ... D. Armstrong in InflammoPharmacology
    Article 01 June 2000

  12. Biotransformation of BOF-4272, a sulfoxide-containing drug, in the cynomolgus monkey

    BOF-4272, (±)-8-(3-methoxy-4-phenylsulfinylphenyl) pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one), is a new drug intended for the treatment of...

    S. Naito, M. Nishimura, Y. ** in European Journal of Drug Metabolism and Pharmacokinetics
    Article 01 September 1999

  13. S

    Ian K. M. Morton, Judith M. Hall in Concise Dictionary of Pharmacological Agents
    Chapter 1999

  14. F

    Ian K. M. Morton, Judith M. Hall in Concise Dictionary of Pharmacological Agents
    Chapter 1999

  15. A

    Ian K. M. Morton, Judith M. Hall in Concise Dictionary of Pharmacological Agents
    Chapter 1999

  16. Qualitative and Quantitative Assessment of Platelet Activating Factors

    Platelet-activating factor (PAF) often is viewed as a single molecular entity with defined biological activities and potencies. It is now clear,...
    R. N. Pinckard, D. S. Woodard, ... L. M. McManus in Platelets and Their Factors
    Chapter 1997

  17. A

    Paul Turner, Glyn Volans, Heather Wiseman in Drugs Handbook 1996–97
    Chapter 1996

  18. S

    Paul Turner, Glyn Volans, Heather Wiseman in Drugs Handbook 1995–96
    Chapter 1996

  19. S

    Paul Turner, Glyn Volans, Heather Wiseman in Drugs Handbook 1996–97
    Chapter 1996

  20. Drug Interactions at Plasma and Tissue Binding Sites

    The binding of drugs to plasma and tissue proteins is a major determinant of drug distribution throughout the body. This binding has also a very...
    J. C. McElnay in Mechanisms of Drug Interactions
    Chapter 1996
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