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Seasonal malaria chemoprevention in a context of high presumed sulfadoxine-pyrimethamine resistance: malaria morbidity and molecular drug resistance profiles in South Sudan
BackgroundSeasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine plus amodiaquine (SP-AQ), is a community-based malaria preventive...
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Molecular surveillance for anti-malarial drug resistance and genetic diversity of Plasmodium falciparum after chloroquine and sulfadoxine-pyrimethamine withdrawal in Quibdo, Colombia, 2018
BackgroundResistance to anti-malarial drugs is associated with polymorphisms in target genes and surveillance for these molecular markers is...
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Effects of maternal antenatal treatment with two doses of azithromycin added to monthly sulfadoxine-pyrimethamine for the prevention of low birth weight in Burkina Faso: an open-label randomized controlled trial
BackgroundExposure during pregnancy to malaria and sexually-transmitted infections is associated with adverse birth outcomes including low birth...
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A snapshot of the prevalence of dihydropteroate synthase-431V mutation and other sulfadoxine-pyrimethamine resistance markers in Plasmodium falciparum isolates in Nigeria
BackgroundMalaria is a major public health issue with substantial risks among vulnerable populations. Currently, the World Health Organization (WHO)...
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Sub-microscopic Plasmodium falciparum parasitaemia, dihydropteroate synthase (dhps) resistance mutations to sulfadoxine–pyrimethamine, transmission intensity and risk of malaria infection in pregnancy in Mount Cameroon Region
BackgroundPlasmodium falciparum resistance to intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) continues to spread...
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Effect of three years’ seasonal malaria chemoprevention on molecular markers of resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine and amodiaquine in Ouelessebougou, Mali
BackgroundIn 2012, seasonal malaria chemoprevention (SMC) was recommended as policy for malaria control by the World Health Organization (WHO) in...
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Intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine and parasite resistance: cross-sectional surveys from antenatal care visit and delivery in rural Ghana
BackgroundDespite decades of prevention efforts, the burden of malaria in pregnancy (MiP) remains a great public health concern....
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Uptake of intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) in Uganda: a national survey
BackgroundIn spite of the missed opportunities of sulfadoxine-pyrimethamine (IPTp-SP) in Uganda, scanty literature exist on malaria in pregnancy. To...
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Stable high frequencies of sulfadoxine–pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine–pyrimethamine in Ujjain, Madhya Pradesh, India
BackgroundArtesunate plus sulfadoxine–pyrimethamine (ASP) is first-line treatment for uncomplicated Plasmodium falciparum malaria in most of India,...
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Malaria Drug Discovery: How to Tackle the Problem of Drug Resistance
Malaria has been a huge issue in previous years since it is an endemic disease that kills millions of people worldwide, regardless of their age....
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Risk factors for placental malaria, sulfadoxine-pyrimethamine doses, and birth outcomes in a rural to urban prospective cohort study on the Bandiagara Escarpment and Bamako, Mali
BackgroundMalaria in Mali remains a primary cause of morbidity and mortality, with women at high risk during pregnancy for placental malaria (PM)....
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Sulfadoxine-pyrimethamine parasitological efficacy against Plasmodium falciparum among pregnant women and molecular markers of resistance in Zambia: an observational cohort study
BackgroundThe World Health Organization recommends the provision of intermittent preventive treatment during pregnancy (IPTp) with...
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Assessment of Plasmodium falciparum drug resistance associated molecular markers in Mandla, Madhya Pradesh, India
BackgroundResistance against artemisinin-based combination therapy is one of the challenges to malaria control and elimination globally. Mutations in...
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Temporal evolution of sulfadoxine-pyrimethamine resistance genotypes and genetic diversity in response to a decade of increased interventions against Plasmodium falciparum in northern Ghana
BackgroundAnti-malarial drug resistance remains a key concern for the global fight against malaria. In Ghana sulfadoxine-pyrimethamine (SP) is used...
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Antimalarial Drugs and Drug Resistance
WHO estimated 241 million malaria cases in 2020 in 85 different malaria-endemic countries, more than in 2019. The reduction of cases due to...
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Molecular surveillance of anti-malarial drug resistance genes in Plasmodium falciparum isolates in Odisha, India
BackgroundDespite significant progress in eliminating malaria from the state of Odisha, India, the disease is still considered endemic. Artesunate...
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Artemisinin Resistance in Plasmodium falciparum Malaria
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in recent years to a substantial reduction in deaths resulting...
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Plasmodium falciparum drug resistance-associated mutations in isolates from children living in endemic areas of Burkina Faso
BackgroundArtemisinin-based combinations therapy (ACT) is the current frontline curative therapy for uncomplicated malaria in Burkina Faso....
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Assessment of genetic polymorphisms associated with malaria antifolate resistance among the population of Libreville, Gabon
BackgroundGabon is a malaria-threatened country with a stable and hyperendemic transmission of Plasmodium falciparum monoinfection. Malaria drug...
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Increased prevalence of pfdhfr and pfdhps mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates from Jazan Region, Southwestern Saudi Arabia: important implications for malaria treatment policy
BackgroundDespite significant progress in eliminating malaria from the Kingdom of Saudi Arabia, the disease is still endemic in the southwestern...
