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Comparative pathogenicity of drug-resistant and drug-sensitive Trypanosoma brucei and Trypanosoma congolense infections in Nigerian local dogs
Animal trypanosomosis is an important endemic and wasting disease in sub-Saharan Africa. Its control relies on chemotherapy, and resistance to...
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The prevalence and density of asymptomatic Plasmodium falciparum infections among children and adults in three communities of western Kenya
BackgroundFurther reductions in malaria incidence as more countries approach malaria elimination require the identification and treatment of...
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Detection of asymptomatic malaria in Asian countries: a meta-analysis of diagnostic accuracy
BackgroundAchieving malaria elimination requires the targeting of the human reservoir of infection, including those patients with asymptomatic...
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Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers
BackgroundDiverse vaccination outcomes and protection levels among different populations pose a serious challenge to the development of an effective...
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Just-In-Time Education of FDA Regulation and Protection of Intellectual Property for Medical Products: A Course Review After Our First 10 Years
Successful translation of medical devices requires a clear pathway through the business environment, including regulatory obligations and the...
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Asymptomatic Plasmodium falciparum carriage and clinical disease: a 5-year community-based longitudinal study in The Gambia
BackgroundCarriers of persistent asymptomatic Plasmodium falciparum infections constitute an infectious reservoir that maintains malaria...
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Dose prediction of organs at risk in patients with cervical cancer receiving brachytherapy using needle insertion based on a neural network method
ObjectiveA neural network method was employed to establish a dose prediction model for organs at risk (OAR) in patients with cervical cancer...
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The HBV capsid modulators derived from sulfamoylbenzamides and benzamides: an overview of the progress of patents
Hepatitis B virus (HBV) capsid assembly has become an attractive target for the therapy of chronic HBV infection. Since the first report of...
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Patent Law Fundamentals for Biomedical Scientists
The major objective of this 2-part chapter is to introduce, demystify and advance the knowledge of patent law among biomedical scientists. Part I...
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Clinical Presentation and Therapy of Tetralogy of Fallot and Double-Outlet Right Ventricle
Tetralogy of Fallot (TOF) is the most common cyanotic heart defect. TOF consists of the combination of four anomalies (Fig. 35.1): (1) a large...
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Ethics and regulation of neuronal optogenetics in the European Union
Neuronal optogenetics is a technique to control the activity of neurons with light. This is achieved by artificial expression of light-sensitive ion...
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Additional burden of asymptomatic and sub-patent malaria infections during low transmission season in forested tribal villages in Chhattisgarh, India
BackgroundThe burden of sub-patent malaria is difficult to recognize in low endemic areas due to limitation of diagnostic tools, and techniques....
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Modified mRNA Versus Unmodified mRNA: Not just a Scientific Issue
To conclude this section on seminal studies and initial preclinical and clinical experiments with mRNA, a comparative analysis of the use of...
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Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies
Recent advances in immuno-oncology have opened up new and impressive treatment options for cancer. Notwithstanding, overcoming the limitations of the...
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Towards ethical drug pricing: the European Orphan Genomic Therapies Fund
An increasing number of novel genomic therapies are expected to become available for patients with rare or ultra-rare diseases. However, the primary...
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Role of Herbal Formulations in Antiviral Therapy - an Overview
The incidence and prevalence of various viral infections have risen tremendously and remain a life-threatening risk to people over the past century....
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The History of the Loa loa Parasite, Its Biology and Experimental Models
Loiasis affects an estimated population of 14.4 million people living in rainforest areas of West and Central Africa. Although the disease is known...
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Diagnostic challenges for Aelurostrongylus abstrusus infection in cats from endemic areas in Italy
BackgroundThe lungworm Aelurostrongylus abstrusus infects wild and domestic feline species worldwide and is considered a primary respiratory...
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Plasmodium pitheci malaria in Bornean orang-utans at a rehabilitation centre in West Kalimantan, Indonesia
BackgroundPlasmodial species naturally infecting orang-utans, Plasmodium pitheci and Plasmodium silvaticum , have been rarely described and...
