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Topological analysis of sharp-wave ripple waveforms reveals input mechanisms behind feature variations
The reactivation of experience-based neural activity patterns in the hippocampus is crucial for learning and memory. These reactivation patterns and...
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A feature-specific prediction error model explains dopaminergic heterogeneity
The hypothesis that midbrain dopamine (DA) neurons broadcast a reward prediction error (RPE) is among the great successes of computational...
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A neuropathologic feature of brain aging: multi-lumen vascular profiles
Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs),...
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Expanding the speech and language phenotype in Koolen-de Vries syndrome: late onset and periodic stuttering a novel feature
Speech and language impairment is core in Koolen-de Vries syndrome (KdVS), yet only one study has examined this empirically. Here we define speech,...
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Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease
A central event in the pathogenesis of motor neuron disease (MND) is the loss of neuromuscular junctions (NMJs), yet the mechanisms that lead to this...
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CHESS enables quantitative comparison of chromatin contact data and automatic feature extraction
Dynamic changes in the three-dimensional (3D) organization of chromatin are associated with central biological processes, such as transcription,...
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Expression of SATB1 and SATB2 in the brain of bony fishes: what fish reveal about evolution
Satb1 and Satb2 belong to a family of homeodomain proteins with highly conserved functional and regulatory mechanisms and posttranslational...
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Location-specific signatures of Crohn’s disease at a multi-omics scale
BackgroundCrohn’s disease (CD), an inflammatory bowel disease (IBD) subtype, results from pathologic interactions between host cells and its resident...
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Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients
Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still...
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Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation
The principal hallmark of Parkinson’s disease (PD) is the selective neurodegeneration of dopaminergic neurones. Mounting evidence suggests that...
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Chronic flaccid quadriparesis from tract specific myelopathy in neurosyphilis
IntroductionTract-specific myelopathies with distinctive imaging features are uncommon and typically occur with metabolic or paraneoplastic...
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Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases
BackgroundGenome-wide association studies (GWAS) have identified pervasive sharing of genetic architectures across multiple immune-mediated diseases...
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Does context recollection depend on the base-rate of contextual features?
Episodic recollection is defined by the re-experiencing of contextual and target details of a past event. The base-rate dependency hypothesis assumes...
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Memory and Classification in the Brain and in Artificial Systems
Memory is vital to the functioning of advanced nervous systems as well as to artificial networks that require training (hence most of the interesting...
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Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line
Amongst omics technologies, metabolomics should have particular value in regulatory toxicology as the measurement of the molecular phenotype is the...
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Parameterized aperiodic and periodic components of single-channel EEG enables reliable seizure detection
Although it is clinically important, a reliable and economical solution to automatic seizure detection for patients at home is yet to be developed....
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Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease
Prion diseases are neurodegenerative disorders with long asymptomatic incubation periods, followed by a rapid progression of cognitive and functional...
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Laser spectroscopic method for remote sensing of respiratory rate
Noncontact sensing methods for measuring vital signs have recently gained interest, particularly for long-term monitoring. This study introduces a...
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Interactions of Cellular Energetic Gene Clusters in the Alzheimer’s Mouse Brain
Alzheimer’s disease (AD) is the most common cause of dementia in the aging population. The pathological characteristics include extracellular senile...
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Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus
An essential feature of neurons is their ability to centrally integrate information from their dendrites. The activity of astrocytes, in contrast,...
