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Neuroactive Steroids
Neuroactive steroids regulate neuronal and glial function via non-genomic mechanisms by interacting with ion channels and neurotransmitter receptors....
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Biotransformation of Steroids: History, Current Status, and Future Prospects
Spreading of new diseases has elevated the need to synthesis novel derivatives from currently used drugs. Corticosteroidal drugs are potent drugs...
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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes
Drug efficacy is dependent on the pharmacokinetics and pharmacodynamics of therapeutic agents. Tight junctions, detoxification enzymes, and drug...
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Effect of use of NSAIDs or steroids during the acute phase of pain on the incidence of chronic pain: a systematic review and meta-analysis of randomised trials
BackgroundThis study is the first to summarize the evidence on how the use of anti-inflammatory drugs during acute pain has an impact on the...
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The toxic effects of anabolic steroids “nandrolone decanoate” on cardiac and skeletal muscles with the potential ameliorative effects of silymarin and fenugreek seeds extract in adult male albino rats
BackgroundAnabolic steroids (AS) are commonly abused by body builders and athletes aiming to increase their strength and muscle mass but...
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Clinical use of steroids in viral central nervous system (CNS) infections: three challenging cases
The role of adjunctive corticosteroids in reducing morbidity and mortality of viral CNS infections remains poorly defined. Clinicians are often left...
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Sex Steroids and Their Influence in Lung Diseases Across the Lifespan
The economic burden of lung diseases continues to be on the rise, with increasing annual expenditures every year. However, the pathophysiology of...
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Medaka embryos as a model for metabolism of anabolic steroids
In anti-do** science, the knowledge of drug metabolism is a prerequisite to identify analytical targets for the detection of misused prohibited...
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Microfluidic encapsulation of enzymes and steroids within solid lipid nanoparticles
The production of solid lipid nanoparticles (SLNs) is challenging, especially when considering the incorporation of biologics. A novel in-house...
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Theory of mind in users of anabolic androgenic steroids
RationaleAnabolic androgenic steroids are used to improve physical performance or increase lean muscle mass. About one-third of users develop a...
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Hormones and Steroids as Neurotransmitters
Neurotransmitters are chemical messengers synthesized by neurons, which enable interconnection of nerve fibers within their vicinity....
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A case report of Kaposiform haemangioendothelioma; response with propranolol and steroids
BackgroundKaposiform haemangioendothelioma is a rare vascular tumor and may involve skin, deep soft tissue or bone. It is a locally aggressive tumor...
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Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Göttingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova)
The probiotic medicinal product TSO ( Trichuris suis ova) is administered to patients with active ulcerative colitis in an ongoing clinical phase IIb...
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Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status
BackgroundGonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic...
