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Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity
BackgroundLung cancer is the leading cause of cancer-related death worldwide, and the timely and serial assessment of low-dose computed tomography...
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Autoantibodies, antigen-autoantibody complexes and antigens complement CA125 for early detection of ovarian cancer
BackgroundMultiple antigens, autoantibodies (AAb), and antigen-autoantibody (Ag-AAb) complexes were compared for their ability to complement CA125...
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CLASSIFICATION OF MEDICAL IMAGES BASED ON THE SPECTRA OF LOCAL WINDOWS
A method for automated classification of medical images using neural networks is presented. The method includes an image segmentation stage at which...
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Diagnostic accuracy of intraoperative frozen section for margin evaluation of oral cavity squamous cell carcinoma
ObjectivesIntraoperative frozen-section evaluation is a valuable technique for detecting positive margins intraoperatively for oral squamous cell...
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A spectroscopic liquid biopsy for the earlier detection of multiple cancer types
BackgroundA rapid, low-cost blood test that can be applied to reliably detect multiple different cancer types would be transformational.
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Identification of a circulating long non-coding RNA signature panel in plasma as a novel biomarker for the detection of acute/early-stage HIV-1 infection
BackgroundIndividuals with acute / early HIV-1 infection are often unaware that they are infected with HIV-1 and may be involved in high-risk...
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Diagnosing and staging epithelial ovarian cancer by serum glycoproteomic profiling
BackgroundThere is a need for diagnostic tests for screening, triaging and staging of epithelial ovarian cancer (EOC). Glycoproteomics of blood...
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HepaClear, a blood-based panel combining novel methylated CpG sites and protein markers, for the detection of early-stage hepatocellular carcinoma
BackgroundEarly screening and detection of hepatocellular carcinoma (HCC) can efficiently improve patient prognosis. We aimed to identify a series of...
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Immunological Markers for Central Nervous System Glia
Glial cells in the central nervous system (CNS) are composed of oligodendrocytes, astrocytes and microglia. They contribute more than half of the...
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Large-scale pancreatic cancer detection via non-contrast CT and deep learning
Pancreatic ductal adenocarcinoma (PDAC), the most deadly solid malignancy, is typically detected late and at an inoperable stage. Early or incidental...
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Retrospective analysis of the 18F-FDG PET/CT cutoff value for metabolic parameters was performed as a prediction model to evaluate risk factors for endometrial cancer
PurposeThe study retrospectively analyzed the accuracy and predictive ability of preoperative integrated whole-body 18 F-FDG PET/CT for the...
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Plasma Metabolic Analysis Reveals the Dysregulation of Short-Chain Fatty Acid Metabolism in Parkinson’s Disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by high morbidity, high disability rate, and slow course of...
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Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis
BackgroundExtracellular vesicle (EV) biomarkers have promising diagnosis and screening capacity for several cancers, but the diagnostic value for...
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Serum neurofilament indicates accelerated neurodegeneration and predicts mortality in late-stage Parkinson’s disease
Different stages of Parkinson’s disease (PD) are defined by clinical criteria, while late-stage PD is marked by the onset of morbidity milestones and...
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Clinical value of circulating tumor cells and hematological parameters in 617 Chinese patients with colorectal cancer: retrospective analysis
BackgroundCirculating tumor cells (CTCs) have been a non-invasive technique which allows investigation of tumor characteristics. The purpose of this...
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Molecular alterations and clinical prognostic factors in resectable non-small cell lung cancer
BackgroundEGFR inhibitor and immunotherapy have been approved for adjuvant treatment in resectable non-small cell lung cancer (NSCLC). Limited...
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Cancer Biomarkers in Diagnosis and Therapeutics
This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer...
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HOXA9 gene promotor methylation and copy number variation of SOX2 and HV2 genes in cell free DNA: A potential diagnostic panel for non-small cell lung cancer
BackgroundMost cases of lung cancer are diagnosed at advanced stage. Detection of genetic and epigenetic markers in cell-free DNA (cfDNA) is a...
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Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
Inhibition of angiogenesis is an important mode of action for the teratogenic effect of chemicals and drugs. There is a gap in the availability of...
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Diagnostic efficacy of contrast-enhanced gastric ultrasonography in staging gastric cancer: a meta-analysis
BackgroundAs comprehensive surgical management for gastric cancer becomes increasingly specialized and standardized, the precise differentiation...
