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Sleep and cancer recurrence and survival in patients with resected Stage III colon cancer: findings from CALGB/SWOG 80702 (Alliance)
BackgroundWe sought to assess the influences of sleep duration, sleep adequacy, and daytime sleepiness on survival outcomes among Stage III colon...
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mFOLFIRINOX versus mFOLFOX 6 as adjuvant treatment for high-risk stage III colon cancer - the FROST trial: study protocol for a multicenter, randomized controlled, phase II trial
BackgroundHigh-risk stage III colon cancer has a considerably poorer prognosis than stage II and low-risk stage III colon cancers. Nevertheless, most...
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Lymphovascular invasion represents a superior prognostic and predictive pathological factor of the duration of adjuvant chemotherapy for stage III colon cancer patients
BackgroundLymphovascular invasion (LVI) and perineural invasion (PNI) can indicate poor survival outcomes in colorectal cancer, but few studies have...
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Effects of deficient mismatch repair on the prognosis of patients with stage II and stage III colon cancer during different postoperative periods
BackgroundWe evaluated the prognostic role of deficient mismatch repair (dMMR) systems in stage II and stage III colon cancer patients during...
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Number of negative lymph nodes with a positive impact on survival of stage III colon cancer; a retrospective observation study for right side and left side colon
BackgroundThe purpose was to examine the effect of negative lymph nodes (NLN) number on survival in stage III colon cancer. To reduce the...
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KCNQ1 and lymphovascular invasion are key features in a prognostic classifier for stage II and III colon cancer
BackgroundThe risk of recurrence after resection of a stage II or III colon cancer, and therefore qualification for adjuvant chemotherapy (ACT), is...
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Functional proteomics of colon cancer Consensus Molecular Subtypes
BackgroundThe Colorectal Cancer Subty** Consortium established four Consensus Molecular Subtypes (CMS) in colorectal cancer: CMS1...
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The effects of oxaliplatin-based adjuvant chemotherapy in high-risk stage II colon cancer with mismatch repair-deficient: a retrospective study
BackgroundFor high-risk stageIImismatch repair deficient (dMMR) colon cancers, the benefit of adjuvant chemotherapy remains debatable. The principal...
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Evaluation of a 55-gene classifier as a prognostic biomarker for adjuvant chemotherapy in stage III colon cancer patients
BackgroundAdjuvant chemotherapy reduces the risk of recurrence of stage III colon cancer (CC). However, more effective prognostic and predictive...
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Interaction analysis of high-risk pathological features on adjuvant chemotherapy survival benefit in stage II colon cancer patients: a multi-center, retrospective study
BackgroundWe aimed to analyze the benefit of adjuvant chemotherapy in high-risk stage II colon cancer patients and the impact of high-risk factors on...
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How ceramides affect the development of colon cancer: from normal colon to carcinoma
The integrity of the colon and the development of colon cancer depend on the sphingolipid balance in colon epithelial cells. In this review, we...
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Role of Block Copolymers in Colon Cancer
Block copolymers are progressively being taken into consideration, particularly as carriers for the pharmacotherapy & management of different...
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The efficacy of adjuvant chemotherapy for older adults with stage II/III gastric cancer: a retrospective cohort study
BackgroundAdjuvant chemotherapy is recommended as the standard treatment for patients with stage II/III resected gastric cancer. However, it is...
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Development and validation of prognostic nomograms based on De Ritis ratio and clinicopathological features for patients with stage II/III colorectal cancer
BackgroundMetabolic derangements and systemic inflammation are related to the progression of colorectal cancer (CRC) and the prognoses of these...
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The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
BackgroundTumor-associated macrophages (TAMs) are associated with unfavorable patient prognosis in many cancer types. However, TAMs are a...
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Evaluation of rs10811661 polymorphism in CDKN2A / B in colon and gastric cancer
One of the causes of colon and gastric cancer is the dysregulation of carcinogenic genes, tumor inhibitors, and micro-RNA. The purpose of this study...
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High- or low-dose preoperative ipilimumab plus nivolumab in stage III urothelial cancer: the phase 1B NABUCCO trial
Cohort 1 of the phase 1B NABUCCO trial showed high pathological complete response (pCR) rates with preoperative ipilimumab plus nivolumab in stage...
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Persistent high levels of carcinoembryonic antigen after tumor resection are associated with poorer survival outcomes in patients with resected colon cancer
BackgroundInterindividual survival and recurrence rates in cases of locoregional colon cancer following surgical resection are highly variable. The...
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Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapse
BackgroundOpting for or against the administration of adjuvant chemotherapy in therapeutic management of stage II colon cancer remains challenging....
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Ubiquitinomics revealed disease- and stage-specific patterns relevant for the 3PM approach in human sigmoid colon cancers
ObjectiveThe patients with sigmoid colorectal cancer commonly show high mortality and poor prognosis. Increasing evidence has demonstrated that the...
