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Human Sporadic Prion Diseases
Sporadic or idiopathic prion diseases account for over 90% of all human prion diseases, and sporadic Creutzfeldt–Jakob disease (sCJD) is by far the... -
Analysis of Genetic Factors of Sporadic Schizophrenia in Family Trios Using Whole-Genome Sequencing
Schizophrenia is a mental disorder, the hereditary nature of which has been confirmed by numerous studies. Currently, more than a hundred genetic...
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Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson’s disease
Deficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are...
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Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer’s disease with multi-modal PET and plasma GFAP
BackgroundPlasma assays for the detection of Alzheimer’s disease neuropathological changes are receiving ever increasing interest. The concentration...
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MST1 selective inhibitor Xmu-mp-1 ameliorates neuropathological changes in a rat model of sporadic Alzheimer’s Disease by modulating Hippo-Wnt signaling crosstalk
Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by progressive cognitive impairment accompanied by aberrant neuronal...
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Associations of Reported Genetic Risk Loci with Sporadic Brain Arteriovenous Malformations: Meta-analysis
An arteriovenous malformation (AVM) is an abnormal nidus of blood vessels that is characterized by a direct connection between arteries and veins...
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Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers
BackgroundVascular dysfunction was recently reported to be involved in the pathophysiological process of neurodegenerative diseases, but its role in...
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Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease
Peripheral inflammatory immune responses are thought to play a major role in the pathogenesis of Parkinson’s disease (PD). The...
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A Mouse Model of Sporadic Alzheimer’s Disease with Elements of Major Depression
After olfactory bulbectomy, animals are often used as a model of major depression or sporadic Alzheimer’s disease and, hence, the status of this...
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Transcriptomic profiling of sporadic Alzheimer’s disease patients
Alzheimer’s disease (AD) manifested before age 65 is commonly referred to as early-onset AD (EOAD) (Reitz et al. Neurol Genet. 2020;6:e512). While...
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Genetic analysis of 106 sporadic cases with hearing loss in the UAE population
BackgroundHereditary hearing loss is a rare hereditary condition that has a significant presence in consanguineous populations. Despite its...
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LINC complex alterations are a key feature of sporadic and familial ALS/FTD
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and...
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CDiP technology for reverse engineering of sporadic Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disease that causes cognitive impairment for which neither treatable nor preventable approaches have...
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Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations
Loss of function progranulin ( GRN ) mutations are a major autosomal dominant cause of frontotemporal dementia (FTD). Patients with FTD due to GRN ...
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MSC-Derived Extracellular Vesicles Alleviate NLRP3/GSDMD-Mediated Neuroinflammation in Mouse Model of Sporadic Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease, with sporadic form being the predominant type. Neuroinflammation plays a...
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Glycoform-Selective Prions in Sporadic and Genetic Variably Protease-Sensitive Prionopathies
Unlike other human prion diseases, including the most common Creutzfeldt–Jakob disease (CJD), variably protease-sensitive prionopathy (VPSPr) is... -
Exendin-4 Prevents Memory Loss and Neuronal Death in Rats with Sporadic Alzheimer-Like Disease
This study investigated the neuroprotective effects of exendin-4 (EXE-4), an analog of the glucagon-like peptide 1 receptor (GLP-1R) on memory and on...
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Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson’s disease patients
Parkinson’s disease (PD) is a neurodegenerative disease with both genetic and sporadic origins. In this study, we investigated the...
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PREMM5 distinguishes sporadic from Lynch syndrome-associated MMR-deficient/MSI-high colorectal cancer
Current algorithms for diagnosing Lynch syndrome (LS) include multistep molecular tumor tests to distinguish LS-associated from sporadic colorectal...
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Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies
Acquired sporadic late onset nemaline myopathy (SLONM) and inherited nemaline myopathy (iNM) both feature accumulation of nemaline rods in muscle...