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Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer
BackgroundAlternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently...
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PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic syndromes
BackgroundSplicing factors are frequently mutated in patients with myelodysplastic syndromes and acute myeloid leukaemia. Recent studies have...
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Splicing factor-mediated regulation patterns reveals biological characteristics and aid in predicting prognosis in acute myeloid leukemia
BackgroundAlternative splicing (AS) of RNA is a fundamental biological process that shapes protein diversity. Many non-characteristic AS events are...
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Characterization of a Novel F5 Intronic Variant Associated with Aberrant Splicing and Severe Factor V Deficiency
Congenital factor V (FV) deficiency is a rare autosomal recessive bleeding disorder caused by defects in the F5 gene associated with bleeding...
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TRIM25 promotes glioblastoma cell growth and invasion via regulation of the PRMT1/c-MYC pathway by targeting the splicing factor NONO
BackgroundUbiquitination plays an important role in proliferating and invasive characteristic of glioblastoma (GBM), similar to many other cancers....
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Role of epithelial splicing regulatory protein 1 in cancer progression
As aberrant alternative splicing by either dysregulation or mutations of splicing factors contributes to cancer initiation and progression, splicing...
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Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem...
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Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative splicing
BackgroundDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets....
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Genetic Mutations and Alternative Splicing in Schizophrenia
Genetic mutations are responsible for most neurogenetic disorders. Schizophrenia is a neurogenetic disorder; we focused on genetic mutations and...
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Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing
BackgroundImmunotherapies effectively treat human malignancies, but the low response and resistance are major obstacles. Neoantigen is an emerging...
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Dysregulation of alternative splicing contributes to multiple myeloma pathogenesis
BackgroundDysregulation of alternative splicing (AS) triggers many tumours, understanding the roles of splicing events during tumorigenesis would...
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Biological relevance of alternative splicing in hematologic malignancies
Alternative splicing (AS) is a strictly regulated process that generates multiple mRNA variants from a single gene, thus contributing to proteome...
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The role of alternative pre-mRNA splicing in cancer progression
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the...
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SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis
BackgroundAberrant alternative splicing (AS) is a pervasive event during colorectal cancer (CRC) development. SF3B3 is a splicing factor component of...
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Circulating small extracellular vesicle-derived splicing factor 3b subunit 4 as a non-invasive diagnostic biomarker of early hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) accounts for a majority of primary liver cancer cases and related deaths. The purpose of this study was to...
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Alternative splicing in neurodegenerative disease and the promise of RNA therapies
Alternative splicing generates a myriad of RNA products and protein isoforms of different functions from a single gene. Dysregulated alternative...
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RNA splicing dysregulation and the hallmarks of cancer
Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types. Cancer-associated splicing alterations arise from both...
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Gene expression and alternative splicing contribute to adaptive divergence of ecotypes
Regulation of gene expression is a critical link between genotype and phenotype explaining substantial heritable variation within species. However,...
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The implications of alternative pre-mRNA splicing in cell signal transduction
Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing,...
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Alternative splicing and environmental adaptation in wild house mice
A major goal of evolutionary genetics is to understand the genetic and molecular mechanisms underlying adaptation. Previous work has established that...
