Search
Search Results
-
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation
BackgroundRadioresistance is the major obstacle in radiation therapy (RT) for hepatocellular carcinoma (HCC). Dysregulation of DNA damage response...
-
Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review
Indoor air pollution is becoming a rising public health problem and is largely resulting from the burning of solid fuels and heating in households....
-
Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression
Mycotoxins induce oxidative stress, hypoxia, and cause immunosuppressive effects. Moreover, emerging evidence show that mycotoxins have a potential...
-
Learning from NATO Biomarker Research for Humans
Early knowledge of the absorbed dose is of paramount importance in radiation emergencies in order to focus the available resources only on those...
-
The cross-talk between Bax, Bcl2, caspases, and DNA damage in bystander HepG2 cells is regulated by Îł-radiation dose and time of conditioned media transfer
Although radiation-induced bystander effects have been broadly explored in various biological systems, the molecular mechanisms and the consequences...
-
WEE1 and PARP-1 play critical roles in myelodysplastic syndrome and acute myeloid leukemia treatment
BackgroundMyelodysplastic syndrome (MDS) is a clonal bone marrow disorder defined by cytopenia and is associated with an increased risk of...
-
Effect of asciminib and vitamin K2 on Abelson tyrosine-kinase-inhibitor-resistant chronic myelogenous leukemia cells
BackgroundAbelson (ABL) tyrosine kinase inhibitors (TKIs) are effective against chronic myeloid leukemia (CML); however, many patients develop...
-
Bcl-2-associated transcription factor 1 Ser290 phosphorylation mediates DNA damage response and regulates radiosensitivity in gastric cancer
BackgroundDNA damage response plays critical roles in tumor pathogenesis and radiotherapy resistance. Protein phosphorylation is a critical mechanism...
-
Novel aloe emodin–hydroxyethyl piperazine hybrid dihydrochloride induces oral cancer CAL-27 cells apoptosis through ROS production, DNA damage and mitochondrial pathways
Oral cancer severely affects the quality of life of patients, and the primary treatment is surgery, due to a lack of specific drugs. Aloe emodin, a...
-
Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis
BackgroundTemozolomide (TMZ) treatment efficacy in glioblastoma (GBM) patients has been limited by resistance in the clinic. Currently, there are no...
-
DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration
Neurodegenerative diseases have a complex origin and are composed of genetic and environmental factors. Both DNA damage and chromatin rearrangement...
-
Genotoxicity Evaluation of Nanosized Materials
Nanomaterials possess unique properties and are widely used in various applications such as cosmetics, drug delivery, nanomedicines, tissue...
-
ITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors
BackgroundThe B7-H3 protein, encoded by the CD276 gene, is a member of the B7 family of proteins and a transmembrane glycoprotein. It is highly...
-
Cellular senescence and neurodegeneration
Advancing age is a major risk factor of Alzheimer’s disease (AD). The worldwide prevalence of AD is approximately 50 million people, and this number...
-
HIV Nef enhances the expression of oncogenic c-MYC and activation-induced cytidine deaminase in Burkitt lymphoma cells, promoting genomic instability
BackgroundNon-Hodgkin lymphoma is of high prevalence among HIV-infected people. In particular, the incidence of HIV-associated Burkitt lymphoma (BL)...
-
Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin
BackgroundDNA ligases are crucial for DNA repair and cell replication since they catalyze the final steps in which DNA breaks are joined. DNA Ligase...
-
A multi-biomarker micronucleus assay using imaging flow cytometry
Genetic toxicity testing assesses the potential of compounds to cause DNA damage. There are many genetic toxicology screening assays designed to...
-
Natural Chemopreventive Agents for the Treatment and Prevention of Oral Squamous Cell Carcinoma
Oral cancer is a severe health problem claiming around 120,000 deaths annually, of which 90% is oral squamous cell carcinoma (OSCC). Despite the...
-
Natural Chemopreventive Agents for the Treatment and Prevention of Oral Squamous Cell Carcinoma
Oral cancer is a severe health problem claiming around 120,000 deaths annually, of which 90% is oral squamous cell carcinoma (OSCC). Despite the...
-
Reducing Uncertainties in Live Monitoring of Radiation in Wildlife
Inputs of radionuclides to the environment can result in minor increases in radiation levels for short periods of time, as with the release of...