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Recent progress of small-molecule of RET inhibitors against Non-small cell lung cancer
Since the oncogenic rearranged during transfection (RET) gene fusion was discovered in non-small cell lung cancer (NSCLC) in 2012, multiple-targeted...
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Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma
Neuroblastoma is the most common and deadliest tumor in infancy. WDR5 (WD Repeat Domain 5), a critical factor supporting an N-myc transcriptional...
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Molecular docking and molecular dynamics studies of anti-allergic medicines as inhibitors against COVID-19
The 2019-nCoV virus is a human-infectious coronavirus (CoV). The healthcare workers fighting this outbreak on the front lines have few treatment...
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In-silico identification of small molecule benzofuran-1,2,3-triazole hybrids as potential inhibitors targeting EGFR in lung cancer via ligand-based pharmacophore modeling and molecular docking studies
Lung cancer is one of the most common and deadly types of cancer worldwide, and the epidermal growth factor receptor (EGFR) has emerged as a...
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Computational Chemistry and Molecular Modeling of Reversible MAO Inhibitors
Proper elucidation of drug-target interaction is one of the most significant steps at the early stages of the drug development research....
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Aquaporin Inhibitors
Aquaporins (AQP) working as membrane channels facilitated water transport, play vital roles in various physiological progress including cell...
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Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools
The human equilibrative nucleoside transporter 1 (SLC29A1, hENT1) is a solute carrier that modulates the passive transport of nucleosides and...
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Proactive monitoring of drug–drug interactions between direct oral anticoagulants and small-molecule inhibitors in patients with non-small cell lung cancer
BackgroundSmall-molecule inhibitors (SMIs) have revolutionised the treatment of non-small cell lung cancer (NSCLC). However, SMI-induced drug–drug...
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Cyclin-dependent kinase 7 (CDK7) inhibitors as a novel therapeutic strategy for different molecular types of breast cancer
BACKGROUNDCyclin-dependent kinase (CDK) 7 is aberrantly overexpressed in many types of cancer and is an attractive target for cancer therapy due to...
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Small-Molecule HIV Entry Inhibitors Targeting gp120 and gp41
Interrupting early events in the virus life cycle, such as those prior to the formation of provirus, could effectively prevent HIV-1 infection. HIV-1...
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PARP molecular functions and applications of PARP inhibitors in cancer treatment
Poly(ADP-ribosyl)ation (PARylation), a type of post-translational modification catalyzed by poly(ADP-ribose) polymerase (PARP), is implicated in...
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High-content analysis identified synergistic drug interactions between INK128, an mTOR inhibitor, and HDAC inhibitors in a non-small cell lung cancer cell line
BackgroundThe development of drug resistance is a major cause of cancer therapy failures. To inhibit drug resistance, multiple drugs are often...
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SARS-CoV-2 Resistance to Small Molecule Inhibitors
Purpose of the ReviewSARS-CoV-2 undergoes genetic mutations like many other viruses. Some mutations lead to the emergence of new Variants of Concern...
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Comparison of efficacy and safety between PD-1 inhibitors and PD-L1 inhibitors plus platinum-etoposide as first-line treatment for extensive-stage small-cell lung cancer: a multicenter, real-world analysis
BackgroundImmunotherapy in combination with platinum-etoposide (EP) chemotherapy has been approved as a first-line treatment for extensive-stage...
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Oxidative Stress in Cancer: Therapeutic Implications of Small-Molecule Kinase Inhibitors
Cancer-targeted therapeutics have heavily relied on develo** small-molecule kinase inhibitors as anticancer agents in the last two decades. The...
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Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer
Intensive research in the field of cancer biology has revealed unique methods of communication between cells through extracellular vesicles called...
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Virtual screening of acetylcholinesterase inhibitors through pharmacophore-based 3D-QSAR modeling, ADMET, molecular docking, and MD simulation studies
Alzheimer’s disease (AD) is a leading cause of dementia in elderly patients. The pathophysiology of AD includes various pathways, such as the...
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Progress of immune checkpoint inhibitors therapy for non-small cell lung cancer with liver metastases
Nearly one-fifth of patients with non-small cell Lung Cancer (NSCLC) will develop liver metastases (LMs), and the overall treatment strategy of LMs...
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Oxidative Stress in Cancer: Therapeutic Implications of Small-Molecule Kinase Inhibitors
Cancer-targeted therapeutics have heavily relied on develo** small-molecule kinase inhibitors as anticancer agents in the last two decades. The...
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Discovery of new oxadiazolo pyridine derivatives as potent ghrelin O-acyltransferase inhibitors using molecular modeling techniques
Diabesity is a major global health concern, and ghrelin O-acyltransferase (GOAT) acts as an important target for the development of new inhibitors of...
