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Difference in risk of preterm and small-for-gestational-age birth depending on maternal occupations in Japan
ObjectivesIn this study, an association between the mother’s occupations with preterm and small-for-gestational-age (SGA) births was investigated...
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Comprehensive assessment of the genetic characteristics of small for gestational age newborns in NICU: from diagnosis of genetic disorders to prediction of prognosis
BackgroundIn China, ~1,072,100 small for gestational age (SGA) births occur annually. These SGA newborns are a high-risk population of developmental...
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Methylation analysis by targeted bisulfite sequencing in large for gestational age (LGA) newborns: the LARGAN cohort
BackgroundIn 1990, David Barker proposed that prenatal nutrition is directly linked to adult cardiovascular disease. Since then, the relationship...
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The choice of reference chart affects the strength of the association between malaria in pregnancy and small for gestational age: an individual participant data meta-analysis comparing the Intergrowth-21 with a Tanzanian birthweight chart
BackgroundThe prevalence of small for gestational age (SGA) may vary depending on the chosen weight-for-gestational-age reference chart. An...
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Genome-wide association study of preterm birth and gestational age in a Japanese population
Preterm birth (PTB), defined as the birth of a baby at <37 weeks of gestation, is known to be the main cause of neonatal morbidity and mortality....
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Epigenetic scores derived in saliva are associated with gestational age at birth
BackgroundEpigenetic scores (EpiScores), reflecting DNA methylation (DNAm)-based surrogates for complex traits, have been developed for multiple...
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Ultra-low-coverage genome-wide association study—insights into gestational age using 17,844 embryo samples with preimplantation genetic testing
BackgroundVery low-coverage (0.1 to 1×) whole genome sequencing (WGS) has become a promising and affordable approach to discover genomic variants of...
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Screening of patients born small for gestational age with the Silver-Russell syndrome phenotype for DLK1 variants
Silver–Russell syndrome (SRS) is a rare imprinting disorder associated with prenatal and postnatal growth retardation. Loss of methylation (LOM) on...
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Stability selection enhances feature selection and enables accurate prediction of gestational age using only five DNA methylation sites
BackgroundDNA methylation (DNAm) is robustly associated with chronological age in children and adults, and gestational age (GA) in newborns. This...
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Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines
Adverse birth outcomes, such as early gestational age and low birth weight, can have lasting effects on morbidity and mortality, with impacts that...
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Serum Betatrophin: What It Shows and How It Alters in Gestational Diabetes Mellitus
Gestational diabetes mellitus is defined as diabetes mellitus diagnosed during the second or third trimester of pregnancy and not clearly associated...
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Exploring the potential of microRNA as a diagnostic tool for gestational diabetes
MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating host gene expression. Recent studies have indicated a role of...
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Metabolomic Biomarkers, Metabolite Patterns, and Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with risk of type 2 diabetes (T2D) for mother and offspring....
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Polygenic prediction of preeclampsia and gestational hypertension
Preeclampsia and gestational hypertension are common pregnancy complications associated with adverse maternal and child outcomes. Current tools for...
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An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies
BackgroundGestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using...
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DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort
BackgroundEpigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be...
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Association of ACE*(Insertion/Deletion) Variant with the Elevated Risk of Preeclampsia Among Gestational Women
The renin–angiotensin–aldosterone system has an indispensable function in the uteroplacental circulation, placental growth, and blood pressure...
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Gestational Exposure to Di-n-Butyl Phthalate Induces Autism-Like Behavior Through Inhibition of Neuro-Steroidogenesis
Di-n-butyl phthalate (DBP) is one of the most dominant phthalate esters and is a widely distributed environmental contaminant. The endocrine...
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Serum Betatrophin: What It Shows and How It Alters in Gestational Diabetes Mellitus
Gestational diabetes mellitus is defined as diabetes mellitus diagnosed during the second or third trimester of pregnancy and not clearly associated...
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Chemerin concentrations in infants born small for gestational age: correlations with triglycerides and parameters related to glucose homeostasis
Infants born small for gestational age (SGA) are known to have increased risk of develo** several pathologies, including the metabolic syndrome,...
