Search
Search Results
-
Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes
Previously, we reported a neutralizing monoclonal antibody, A8A11, raised against a novel conserved epitope within the hepatitis C virus (HCV) E2...
-
Potential of an anti-bevacizumab idiotype scFv DNA-based immunization to elicit VEGF-binding antibody response
Anti-idiotype antibodies have been considered for vaccination approaches against different diseases, including cancers. Based on that, we previously...
-
A comprehensive comparison between camelid nanobodies and single chain variable fragments
By the emergence of recombinant DNA technology, many antibody fragments have been developed devoid of undesired properties of natural...
-
Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer
BackgroundChimeric antigen receptor (CAR) -T cell therapy is an efficient therapeutic strategy for specific hematologic malignancies. However,...
-
Isolation of single-chain variable fragment (scFv) antibodies for detection of Chickpea chlorotic dwarf virus (CpCDV) by phage display
Chickpea chlorotic dwarf virus (CpCDV, genus Mastrevirus ), has a wide host range and geographic distribution in many parts of the world, and it is...
-
An oncolytic herpes simplex virus type 1 strain expressing a single-chain variable region antibody fragment against PD-1 and a PI3K inhibitor synergize to elicit antitumor immunity in ovarian cancer
Due to recurrence and resistance to chemotherapy, the current standard therapeutics are not fully effective against ovarian cancer. Therefore, we...
-
-
A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein
BackgroundThe influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is...
-
Cell-penetrating porcine single-chain antibodies (transbodies) against nonstructural protein 1β (NSP1β) of porcine reproductive and respiratory syndrome virus inhibit virus replication
Porcine reproductive and respiratory syndrome virus (PRRSV) causes porcine reproductive and respiratory syndrome (PRRS) worldwide, especially in...
-
Dual Efficacy of a Catalytic Anti-Oligomeric Aβ42 scFv Antibody in Clearing Aβ42 Aggregates and Reducing Aβ Burden in the Brains of Alzheimer’s Disease Mice
One of the primary pathological mechanisms underlying Alzheimer’s disease (AD) is the deposition of amyloid β-protein (Aβ42) aggregates in the brain....
-
Characterization of chimeric antigen receptor modified T cells expressing scFv-IL-13Rα2 after radiolabeling with 89Zirconium oxine for PET imaging
BackgroundChimeric antigen receptor (CAR) T cell therapy is an exciting cell-based cancer immunotherapy. Unfortunately, CAR-T cell therapy is...
-
Inhibitory Effect of Tetramerized Single-Chain Variable Fragment of Anti-Cyclic Citrullinated Peptide Antibodies on the Proliferation, Activation, and Secretion of Cytokines of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis In Vitro Co-Culture System
Tetramerized single-chain variable fragment (ScFv) of anti-cyclic citrullinated peptide (TeAb-CCP) is a constructed tetramerized ScFv of anti-cyclic...
-
Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC
BackgroundChimeric antigen receptor (CAR)-T cells can induce powerful immune responses in patients with hematological malignancies but have had...
-
Improving the cytotoxicity of immunotoxins by reducing the affinity of the antibody in acidic pH
BackgroundImmunotoxins are antibody-toxin conjugates that bind to surface antigens and exert effective cytotoxic activity after internalization into...
-
The development of chimeric antigen receptor T-cells against CD70 for renal cell carcinoma treatment
In this study, we investigated CD70 as a promising target for renal cell carcinoma (RCC) therapy and developed a potent chimeric antigen receptor T...
-
Therapeutic Human Monoclonal Antibodies
Since the discovery of obtaining mouse monoclonal antibodies (MAbs) in 1975 by somatic cell hybridization, there have been rapid developments to use...
-
Nanobody-based CAR-T cells for cancer immunotherapy
Chimeric antigen receptor T-cell (CAR-T) therapy is the result of combining genetic engineering-based cancer immunotherapy with adoptive cell therapy...
-
Haemagglutinin antigen selectively targeted to chicken CD83 overcomes interference from maternally derived antibodies in chickens
Maternally derived antibodies (MDAs) are important for protecting chickens against pathogens in the neonatal stage however, they often interfere with...
-
An auto-antibody identified from phenotypic directed screening platform shows host immunity against EV-A71 infection
BackgroundEnterovirus A71 (EV-A71) is a neurotropic virus which may cause severe neural complications, especially in infants and children. The...
