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Sindbis Virus: Studies of Alphavirus Pathogenesis
Sindbis virus (SINV), an Old World alphavirus, provides a model system for the study of the pathogenesis of viral encephalomyelitis. Investigations...
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Ockelbo Disease in Sweden: Unraveling the Epidemiology, Ecology, and Evolution of Sindbis Virus
This is the story of how an African virus unexpectedly turned up in a village in northern Europe and works of the people who have been involved in...
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DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection
BackgroundRNA helicases are emerging as key factors regulating host-virus interactions. The DEAD-box ATP-dependent RNA helicase DDX5, which plays an...
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Inkoo and Sindbis viruses in blood sucking insects, and a serological study for Inkoo virus in semi-domesticated Eurasian tundra reindeer in Norway
BackgroundMosquito-borne viruses pose a serious threat to humans worldwide. There has been an upsurge in the number of mosquito-borne viruses in...
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Analysis of Synaptic Connections at the Electron Microscopic Level Using Sindbis Virus Vectors
Anterograde tracing using Sindbis virus vector resolves several problems of conventional tracers. Usage of the Sindbis virus as a neural tracer...
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Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers
Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at antigen presentation. Here we report the design and...
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Molecular Biology of Arboviruses
This memoir traces the evolving studies on the molecular biology of arboviruses in the Strauss lab from 1969 to 2007. Jim began working with Sindbis...
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Wolbachia prevalence in the vector species Culex pipiens and Culex torrentium in a Sindbis virus-endemic region of Sweden
BackgroundWolbachia pipientis are endosymbiotic bacteria present in a large proportion of terrestrial arthropods. The species is known to sometimes...
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Pseudotyped Viruses for the Alphavirus Chikungunya Virus
Members of the genus Alphavirus are mostly mosquito-borne pathogens that cause disease in their vertebrate hosts. Chikungunya virus (CHIKV), which is...
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Application of Virus Vectors for Anterograde Tract-Tracing and Single-Neuron Labeling Studies
Elucidating neuronal circuits is fundamental issue for understanding how the brain works and implements higher-order functions. Various viral vectors...
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Vector competence of Swedish Culex pipiens mosquitoes for Japanese encephalitis virus
BackgroundJapanese encephalitis virus (JEV) is an emerging mosquito-borne Orthoflavivirus that poses a significant public health risk in many...
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Viral RNA Is a Hub for Critical Host–Virus Interactions
RNA is a central molecule in the life cycle of viruses, acting not only as messenger (m)RNA but also as a genome. Given these critical roles, it is...
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Lassa Virus Countermeasures
Lassa Fever (LF) is a viral hemorrhagic fever endemic in West Africa. LF begins with flu-like symptoms that are difficult to distinguish from other...
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Upstream Processing of Viral Therapeutics: From Host Cell Expansion to Virus Production
Viral vectors have emerged as a promising approach to treat genetic diseases and cancers, marking the start of a new era in the pharmaceutical...
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Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells
The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a critical role in the xenobiotic and stress responses....
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Evaluating the mosquito host range of Getah virus and the vector competence of selected medically important mosquitoes in Getah virus transmission
BackgroundThe Getah virus (GETV) is a mosquito-borne Alphavirus (family Togaviridae ) that is of significant importance in veterinary medicine. It...
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MVA-based vaccines are protective against lethal eastern equine encephalitis virus aerosol challenge in cynomolgus macaques
MVA-based monovalent eastern equine encephalitis virus (MVA-BN-EEEV) and multivalent western, eastern, and Venezuelan equine encephalitis virus...
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Potassium ion channels as a molecular target to reduce virus infection and mortality of honey bee colonies
Declines in managed honey bee populations are multifactorial but closely associated with reduced virus immunocompetence and thus, mechanisms to...
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Clinical trials of self-replicating RNA-based cancer vaccines
Therapeutic cancer vaccines, designed to activate immune effectors against tumor antigens, utilize a number of different platforms for antigen...
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Evaluation of the vector competence for Batai virus of native Culex and exotic Aedes species in Central Europe
BackgroundBatai virus (BATV) is a zoonotic arbovirus of veterinary importance. A high seroprevalence in cows, sheep and goats and infection in...
