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A quality by design approach in oral extended release drug delivery systems: where we are and where we are going?
BackgroundOral extended release (ER) delivery systems have quickly gained increasing importance because of their ability to maintain drug levels in...
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Drug Release
Drug release from dosage forms (also termed drug liberation) is a prerequisite for absorption to occur: only free molecules in solution can cross...
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Manufacturing Process of Nanoparticles
Nanocarriers have emerged during the past few years as superior carriers and delivery systems for a variety of drugs with low bioavailability when...
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Current application of dexamethasone-incorporated drug delivery systems for enhancing bone formation
BackgroundDexamethasone (DEX) is a well-known anti-inflammatory and immunosuppressive drug applied broadly as an osteoinductive agent in bone...
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Hypericum perforatum: a comprehensive review on pharmacognosy, preclinical studies, putative molecular mechanism, and clinical studies in neurodegenerative diseases
The herb Hypericum perforatum , also referred to as St. John’s wort, has drawn a lot of interest because of its potential therapeutic benefits in...
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Microparticles, Microspheres, and Microemulsions as Pulmonary Drug Delivery Systems for the Treatment of Respiratory Diseases
Lungs present a broad surface area for absorption with extensive blood circulation, increased permeability, and minimal proteolytic activity,...
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Trajectories in nanotechnology: embracing complexity, seeking analogies
This account comprises personal reflections on the field of nanosystems primarily designed for the delivery of biologically active agents. It...
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Microparticles, Microspheres, and Microemulsions in Respiratory Diseases
The term microparticles refers to particles that boast in the size range of micrometers. These may be described as solid particles or particulate...
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Release characteristics of gliclazide in a matrix system
In this study, the release characteristics of gliclazide in a polymeric matrix system, which is used for controlled drug release purposes, are...
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Chitosan-Based Films
The viable alternative to minimize the environmental impact is production of biodegradable polymers. However, synthetic polymers possessing excellent...
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Effect of a Salvia officinalis and Hypericum perforatum mixture on improving memory and cognitive decline
In this study, we explored the effects of herbal mixture containing Sage ( Salvia officinalis ) and St. John’s Wort ( Hypericum perforatum ) on cognitive...
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Solid-State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation
Pharmaceutical systems and products almost always include solid-state ingredients either during manufacture or as the dosage form itself. Thus...
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In Vitro and In Silico ADME Prediction
Pharmacokinetic issues have been identified as a major cause for the attrition of new chemical entities in drug discovery. High development costs and...
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Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats
Chronically stressed patients often have low vagal tone and increased levels of proinflammatory cytokines, which increase their risk for develo**...
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Robustness of Controlled Release Tablets Based on a Cross-linked Pregelatinized Potato Starch Matrix
The aim of this study was to evaluate the potential of a cross-linked pregelatinized potato starch (PREGEFLO® PI10) as matrix former for controlled...
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Interpenetrating Polymer Network in Microparticulate Systems: Drug Delivery and Biomedical Application
The advancement in polymer grafting has played an important role in the evolution of interpenetrating polymer network (IPN) systems....
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Cellulose and its derivatives for application in 3D printing of pharmaceuticals
BackgroundThree-dimensional printing (3DP) has emerged as an advanced manufacturing technology capable of producing complex yet precise medicines...
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Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations
PurposeThe purpose of this study is to show how the Ocular Compartmental Absorption & Transit (OCAT™) model in GastroPlus ® can be used to...
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Muscle Tissue as a Surrogate for In Vitro Drug Release Testing of Parenteral Depot Microspheres
Despite the importance of drug release testing of parenteral depot formulations, the current in vitro methods still require ameliorations in...
