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Knowledge and attitude towards sickle cell anemia among care givers of paediatric sickle cell patients at a tertiary hospital in Eastern Uganda: a cross sectional study
ObjectiveTo explore the knowledge and attitude towards sickle cell disease (SCD) among care givers of paediatric sickle cell patients at Mbale...
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Detection of Transversions and Transitions in HBG2 Cis-Elements Associated with Sickle Cell Allele in Ghanaians
Short tandem repeats located 5ʹ prime to the β-globin gene, have been observed to be in linkage disequilibrium with the HbS allele, and thought to...
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Genetic counseling in sickle cell disease: Insights from the Indian tribal population
Sickle cell disease (SCD) is an inherited disorder of hemoglobin. With an overall prevalence of 4.3%, India is the second-largest hub of SCD after...
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Characterizing Intracranial Hemodynamics in Sickle Cell Anemia: Impact of Patient-Specific Viscosity
PurposePediatric and adult patients with sickle cell anemia (SCA) are at increased risk of stroke and cerebrovascular accident. In the general adult...
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Endline assessment of knowledge about sickle cell disease among the tribal community of Chhotaudepur district of Gujarat
Sickle cell disease (SCD) is a significant public health concern in India, with one of the highest disability burdens worldwide. For the success of...
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Fetal hemoglobin-boosting haplotypes of BCL11A gene and HBS1L-MYB intergenic region in the prediction of clinical and hematological outcomes in a cohort of children with sickle cell anemia
Single nucleotide polymorphisms (SNPs) of BCL11A gene and HBS1L-MYB intergenic region (named HMIP-2) affect both fetal hemoglobin (HbF) concentration...
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Sickle Cell Gene
Sickle cell gene is the signature of distribution of Plasmodium falciparum caused malaria throughout the world. Malaria parasite has imposed strong...
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Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option
Sickle cell disease (SCD) is one of the most common inherited hemoglobinopathy disorders that affects millions of people worldwide. Reactivation of...
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Diagnosis support of sickle cell anemia by classifying red blood cell shape in peripheral blood images
Red blood cell (RBC) deformation is the consequence of several diseases, including sickle cell anemia, which causes recurring episodes of pain and...
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Translating research to usual care of children with sickle cell disease in Northern Nigeria: lessons learned from the SPRING Trial Team
ObjectivesEvidence-based practice for stroke prevention in high-income countries involves screening for abnormal transcranial Doppler (TCD) velocity...
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A phase 1 study in healthy participants to characterize the safety and pharmacology of inclacumab, a fully human anti-P-selectin antibody, in development for treatment of sickle cell disease
PurposeWe evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of intravenous (IV) inclacumab, a fully human IgG4...
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Manifestations of HbSE sickle cell disease: a systematic review
BackgroundSickle cell disease (SCD) is commonly encountered in Africa and Middle Eastern countries. The causative mutation in the gene encoding the...
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Comparative evaluation of different oral iron salts in the management of iron deficiency anemia
BackgroundAnemia affects one-fourth of the world's population and is caused mostly by iron deficiency. Iron supplementation is the most essential...
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Analysis of red blood cells from peripheral blood smear images for anemia detection: a methodological review
Anemia is a blood disorder which is caused due to inadequate red blood cells and hemoglobin concentration. It occurs in all phases of life cycle but...
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Effect of Gum Arabic (Acacia senegal) on C-reactive protein level among sickle cell anemia patients
ObjectivesInflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that...
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Sickle cell trait newborn screen results: disclosure and management
This study aims to evaluate the notification process of sickle cell trait (SCT) identified by newborn screening in Alberta. On April 1, 2019, Alberta...
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Clinical and biochemical characteristics, and outcome in 33 patients with ceftriaxone-induced liver injury
PurposeTo summarize the clinical and biochemical characteristics of patients with ceftriaxone-induced liver injury and guide the selection of safe...