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Development of core–shell structured nanoparticle for sequential release of tariquidar and docetaxel to overcome multi drug-resistant cancer
PurposeWe developed a core–shell (CS) nanoparticle, docetaxel (DTX)-loaded core and tariquidar (TRQ)-loaded shell conjugated with PEG and RIPL...
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Modified Release Solid Oral Dosage Forms
This chapter presents an extensive overview of the concepts of delayed-release, sustained-release, and pulsatile-release for drug delivery....
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Evaluation of Dose-Response Relationship of Permeation Enhancer Isopropyl Myristate Release on Drug Release: Release Enhancement Efficiency and Molecular Mechanism
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their...
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Sequential immunotherapy: towards cures for autoimmunity
Despite major progress in the treatment of autoimmune diseases in the past two decades, most therapies do not cure disease and can be associated with...
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Advancing targeted combination chemotherapy in triple negative breast cancer: nucleolin aptamer-mediated controlled drug release
BackgroundTriple-negative breast cancer (TNBC) is a recurrent, heterogeneous, and invasive form of breast cancer. The treatment of TNBC patients with...
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Interaural Sequential Masking in the Dolphin Auditory System
Studies in a bottlenose dolphin Tursiops truncatus measured the time of release of short-latency auditory evoked potentials (auditory brainstem...
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Regulation of Neurotransmitter Release by K+ Channels
K+ channels play potent roles in the process of neurotransmitter release by influencing the action potential waveform and modulating neuronal...
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Release of Antibodies and Cytokines from B Cells
Autoreactive B cells play a critical role in rheumatoid arthritis (RA). These cells differentiate into long-living memory B cells and...
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Sequential targeting of PARP with carboplatin inhibits primary tumour growth and distant metastasis in triple-negative breast cancer
BackgroundPatients with triple-negative breast cancer (TNBC) develop early recurrence. While PARP inhibitors (PARPi) have demonstrated potential in BRCA1/2...
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Cold-induced vasodilation during sequential immersions of the hand
A common practice for those operating in cold environments includes repetitive glove doffing and donning to perform specific tasks, which creates a...
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AMPA receptor modulation through sequential treatment with perampanel and aniracetam mitigates post-stroke damage in experimental model of ischemic stroke
The present study evaluates the effect of modulating α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor (AMPAR) by inhibiting them in the...
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Clozapine-loaded nanocapsules improve antipsychotic activity in rats: building a sequential PopPK/PD model to discriminate nanocarriers in the preformulation step
PurposeWe investigated the impact of nanoformulations on the dose-exposure-response relationship of clozapine (CZP), a low-solubility antipsychotic...
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Sustain release of dexamethasone from polyvinyl alcohol microparticle produced via coaxial microfluidic system
ObjectivePolyvinyl alcohol (PVA) as a synthetic biopolymer has unique physicochemical properties to achieve an efficient drug carrier. In this study...
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Which one is better for refractory/relapsed acute B-cell lymphoblastic leukemia: Single-target (CD19) or dual-target (tandem or sequential CD19/CD22) CAR T-cell therapy?
CD19 chimeric antigen receptor (CAR) T-cell therapy has shown great success against B-cell acute lymphoblastic leukemia (B-ALL). Tandem and...
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Apoptotic contraction drives target cell release by cytotoxic T cells
Cytotoxic T lymphocytes (CTLs) fight intracellular pathogens and cancer by identifying and destroying infected or transformed target cells
1 . To kill,...
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Preparation of Sustained Release Formulation of Verapamil Hydrochloride Using Ion Exchange Resins
The purpose of this investigation was to formulate and evaluate the interaction between cation exchange resins and verapamil hydrochloride. The...
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Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Nanostructured lipid carriers (NLCs) hold significant promise as drug delivery systems (DDS) owing to their small size and efficient drug-loading...
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Regulation of Ryanodine Receptor-Dependent Neurotransmitter Release by AIP, Calstabins, and Presenilins
Ryanodine receptors (RyRs) are Ca2+ release channels located in the endoplasmic reticulum membrane. Presynaptic RyRs play important roles in...
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Regulation of the hippocampal translatome by Apoer2-ICD release
BackgroundApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor,...
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IL-37 ameliorates myocardial fibrosis by regulating mtDNA-enriched vesicle release in diabetic cardiomyopathy mice
BackgroundDiabetic cardiomyopathy (DCM), a serious complication of diabetes, leads to structural and functional abnormalities of the heart and...
