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Blockade of sympathetic ganglia improves vascular dysfunction in septic shock
Sepsis/septic shock activates the sympathetic nervous system (SNS) to deal with the infection stress. However, an imbalanced or maladaptive response...
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Prostacyclin synthase deficiency exacerbates systemic inflammatory responses in lipopolysaccharide-induced septic shock in mice
ObjectivesSepsis is a systemic inflammatory disorder characterized by life-threateningorgan dysfunction resulting from a dysregulated host response...
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Sodium-glucose cotransporter-2 inhibitor in risk of sepsis/septic shock among patients with type 2 diabetes mellitus—a retrospective analysis of nationwide medical claims data
This research is an attempt to investigate the benefit of sodium-glucose cotransporter-2 inhibitor (SGLT2I) use in patients with diabetes mellitus...
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Comparison between culture-positive and culture-negative septic shock in patients in the emergency department
Culture results of patients with septic shock affect their management strategies, including antibiotic administration. This study aimed to compare...
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Diagnostic value of transpulmonary thermodilution measurements for acute respiratory distress syndrome in a pig model of septic shock
BackgroundNo direct approach assessing pulmonary vascular permeability exists in the current therapeutic strategy for patients with acute respiratory...
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A case report and review of acute cholangitis with septic shock induced by Edwardsiella tarda
BackgroundEdwardsiella tarda ( E. tarda ) is a gram-negative facultative anaerobic bacterium. Gastroenteritis is the most common manifestation of E....
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Presepsin is a more useful predictor of septic AKI and ARDS for very-old sepsis patients than for young sepsis patients in ICUs: a pilot study
ObjectiveSepsis is a syndrome of life-threatening organ dysfunction. This study aimed to determine whether presepsin is a useful predictor of septic...
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Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients
BackgroundAs leading contributors to worldwide morbidity and mortality, sepsis and septic shock are considered a major global health concern....
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Effect of heart rate control with amiodarone infusion on hemodynamic and clinical outcomes in septic shock patients with tachycardia: a prospective, single-arm clinical study
BackgroundKee** the heart rate within the normal range has improved the survival of septic shock patients. Amiodarone could target the underlying...
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A 12-year study evaluating the outcomes and predictors of mortality in critically ill cancer patients admitted with septic shock
BackgroundThough sepsis is common in patients with cancer, there are limited studies that evaluated sepsis and septic shock in this patient...
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Presepsin and platelet to lymphocyte ratio predict the progression of septic subclinical acute kidney injury to septic acute kidney injury: a pilot study
ObjectiveThis study aimed to determine whether presepsin and inflammation-based prognostic scores can predict the progression of septic subclinical...
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Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock
ObjectiveThe aim of this study is to examine the association of hypophosphatemia and hyperphosphatemia on the first day of ICU admission with...
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Micafungin Population PK Analysis in Healthy and Septic Pigs: Can the Septic Porcine Model Predict the Micafungin PK in Septic Patients?
ObjectivesTo describe micafungin pharmacokinetic (PK) alterations of sepsis induced in piglets and to determine whether the porcine septic model is...
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Vital sign differences between septic patients with tetraplegia and paraplegia
Study designRetrospective chart review.
ObjectivesSepsis is a leading preventable cause of death in patients with chronic spinal cord injury (SCI)....
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TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
BackgroundNeuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). It has been...
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Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock
Most bacterial vaccines work for a subset of bacterial strains or require the modification of the antigen or isolation of the pathogen before vaccine...
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Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function
Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure. Mitochondria are essential for cardiomyocyte homeostasis,...
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Once-daily 1 g ceftriaxone optimizes exposure in patients with septic shock and hypoalbuminemia receiving continuous veno-venous hemodiafiltration
PurposeCeftriaxone total and unbound pharmacokinetics (PK) can be altered in critically ill patients with septic shock and hypoalbuminemia receiving...
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Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4/SLC7A11 Signaling Pathway
This study mainly explored the role of nicorandil in regulating ferroptosis and alleviating septic cardiomyopathy through toll-like receptor (TLR)...
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