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AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy
BackgroundDiabetic wounds are one of the long-term complications of diabetes, with a disordered microenvironment, diabetic wounds can easily develop...
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Senescent endothelial cells promote liver metastasis of uveal melanoma in single-cell resolution
BackgroundUveal melanoma (UM), the most common adult intraocular tumor, is characterized by high malignancy and poor prognosis in advanced stages....
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Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy
Pancreatic cancer is one of the deadliest cancers owing to its late diagnosis and of the strong resistance to available treatments. Despite a better...
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Modification of the Properties of Extracellular Matrix of Senescent Mesenchymal Stem Cells
Cell senescence leads to changes in the secretory activity of mesenchymal stem cells (MSC), including proteins of extracellular matrix (ECM). Here we...
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Multiple pathways promote microtubule stabilization in senescent intestinal epithelial cells
Intestinal epithelial cells are critical for gastrointestinal homeostasis. However, their function declines during aging. The aging-related loss of...
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Elimination of Senescent Cells by Polyphenols and Flavonoids
Oxidative stress, oncogenic signaling, DNA damage, or shortened telomeres, among other stimuli, can lead to cellular senescence. Senescent cells...
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Elimination of Senescent Cells by Polyphenols and Flavonoids
Oxidative stress, oncogenic signaling, DNA damage, or shortened telomeres, among other stimuli, can lead to cellular senescence. Senescent cells...
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Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis
BackgroundAdipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inflammatory disease...
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High proportion of circulating CD8 + CD28- senescent T cells is an independent predictor of distant metastasis in nasopharyngeal carcinoma after radiotherapy
BackgroundNasopharyngeal carcinoma (NPC) is a kind of epithelial carcinoma that is common in East and Southeast Asia. Distant metastasis after...
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Immunesenescence and Compromised Removal of Senescent Cells: Implications for Health in Old Age
Cellular senescence is a state of stable cell cycle arrest triggered by internal and external stressors. A major hallmark of senescent cells is the...
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Senescent fibroblast facilitates re-epithelization and collagen deposition in radiation-induced skin injury through IL-33-mediated macrophage polarization
BackgroundThe need for radiotherapy among the elderly rises with increasing life expectancy and a corresponding increase of elderly cancer patients....
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Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain
Alzheimer’s disease (AD) and dementia in general are age-related diseases with multiple contributing factors, including brain inflammation....
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Senescent tumor cells: an overlooked adversary in the battle against cancer
Senescent cells in cancer tissue, including senescent fibroblasts and macrophages, have been reported to increase the malignant potency of cancer...
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Cytotoxic T-Cells Methods and Protocols
This new edition explores lab protocols describing new techniques to study cytotoxic T-cells (CTLs), as well as chapters of a more general discursive...
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Immunosenescence of T cells: a key player in rheumatoid arthritis
IntroductionThe incidence of rheumatoid arthritis (RA) and its complications are expected to increase with age. Remarkably, RA patients were...
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Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction
Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion is now standard therapy, pathological remodelling leading to...
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The diseased kidney: aging and senescent immunology
Immunosenescence is the deterioration of the innate and adaptive immune systems associated with aging and is primarily characterized by a reduction...
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Senescent cancer cell-derived nanovesicle as a personalized therapeutic cancer vaccine
The development of therapeutic cancer vaccines (TCVs) that provide clinical benefits is challenging mainly due to difficulties in identifying...
