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Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation
Epilepsy is not well controlled by current anti-seizure drugs (ASDs). High mobility group box 1 (HMGB1) is a DNA-binding protein in the nucleus...
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(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission
Epilepsy is one common brain disorder, which is not well controlled by current pharmacotherapy. In this study we characterized the therapeutic...
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Privacy-preserving multi-source semi-supervised domain adaptation for seizure prediction
Domain adaptation (DA) has been frequently used to solve the inter-patient variability problem in EEG-based seizure prediction. However, existing DA...
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Machine Learning for Epilepsy: A Comprehensive Exploration of Novel EEG and MRI Techniques for Seizure Diagnosis
PurposeThis work focuses on automated epileptic seizure diagnosis (ESD) and prediction (ESP) to clarify the expanding role of machine learning (ML)...
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Research progress of epileptic seizure prediction methods based on EEG
At present, at least 30% of refractory epilepsy patients in the world cannot be effectively controlled and treated. The suddenness and...
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Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model
Cognitive deficit is a common comorbidity in temporal lobe epilepsy (TLE) and is not well controlled by current therapeutics. How epileptic seizure...
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Clinical, genetic, and cognitive correlates of seizure occurrences in Phelan-McDermid syndrome
BackgroundPhelan-McDermid syndrome (PMS) is a genetic neurodevelopmental disorder caused by SHANK3 haploinsufficiency and is associated with an...
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The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure
Treatment of epilepsy remains a major problem as some epileptic patients do not respond to the current therapeutics. Transient receptor potential...
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Effectual seizure detection using MBBF-GPSO with CNN network
EEG is the most common test for diagnosing a seizure, where it presents information about the electrical activity of the brain. Automatic Seizure...
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Augmented impulsive behavior in febrile seizure-induced mice
Febrile seizure (FS) is one of the most prevalent etiological events in childhood affecting 2–5% of children from 3 months to 5 years old. Debates on...
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Role of Necroptosis, a Regulated Cell Death, in Seizure and Epilepsy
Epilepsy is a chronic neurological disease that is characterized by spontaneous and recurrent seizures. Regulated cell death is a controlled process...
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Parameterized aperiodic and periodic components of single-channel EEG enables reliable seizure detection
Although it is clinically important, a reliable and economical solution to automatic seizure detection for patients at home is yet to be developed....
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Age-Dependent Reduction in the Expression Levels of Genes Involved in Progressive Myoclonus Epilepsy Correlates with Increased Neuroinflammation and Seizure Susceptibility in Mouse Models
Brain aging is characterized by a gradual decline in cellular homeostatic processes, thereby losing the ability to respond to physiological stress....
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Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions
Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available...
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Seizure Rescue Therapies: Comparing Approved and Commonly Used Benzodiazepine Formulations
Acute seizure therapies given out of the hospital are important for interrupting acute repetitive and prolonged seizures and preventing...
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Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats
BackgroundThe brain extracellular fluid (ECF), composed of secreted neurotransmitters, metabolites, peptides, and proteins, may reflect brain...
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Physical Exercise as a Strategy to Reduce Seizure Susceptibility
Neuroprotective and antiepileptogenic therapies have been extensively used for prevention and treatment of epilepsy. This chapter focuses on the...
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Effect of dietary supplementation with Lactobacillus helveticus R0052 on seizure thresholds and antiseizure potency of sodium valproate in mice
ObjectiveBoth animal and human studies, though limited, showed that multi-strain probiotic supplementation may reduce the number of seizures and/or...
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Administration of Curcumin plus Treadmill Exercise Modulate Some Neuronal Enzyme Activities, Redox Markers and BDNF mRNA Expression in Pilocarpine-Induced Epileptic Seizure in Rats
AbstractEpilepsy, a chronic neurological illness, takes a heavy emotional toll on patients and their families. It is one of most neglected...
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Estimating the Parameters of the Epileptor Model for Epileptic Seizure Suppression
Epilepsy is one of the most common brain disorders worldwide, affecting millions of people every year. Given the partially successful existing...
