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Seizure control by adding on other anti-seizure medication on seizure during levetiracetam administration in patients with glioma-related epilepsy
BackgroundEpilepsy is a major symptom in patients with glioma. Levetiracetam (LEV) is recognized as a first-line treatment for glioma-related...
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Chronic stress but not acute stress decreases the seizure threshold in PTZ-induced seizure in mice: role of inflammatory response and oxidative stress
Seizure is paroxysmal abnormal electrical discharges in the cerebral cortex. Inflammatory pathways and oxidative stress are involved in the...
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Research progress of epileptic seizure prediction methods based on EEG
At present, at least 30% of refractory epilepsy patients in the world cannot be effectively controlled and treated. The suddenness and...
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Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model
Cognitive deficit is a common comorbidity in temporal lobe epilepsy (TLE) and is not well controlled by current therapeutics. How epileptic seizure...
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Clinical, genetic, and cognitive correlates of seizure occurrences in Phelan-McDermid syndrome
BackgroundPhelan-McDermid syndrome (PMS) is a genetic neurodevelopmental disorder caused by SHANK3 haploinsufficiency and is associated with an...
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(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission
Epilepsy is one common brain disorder, which is not well controlled by current pharmacotherapy. In this study we characterized the therapeutic...
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Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation
Epilepsy is not well controlled by current anti-seizure drugs (ASDs). High mobility group box 1 (HMGB1) is a DNA-binding protein in the nucleus...
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Effectual seizure detection using MBBF-GPSO with CNN network
EEG is the most common test for diagnosing a seizure, where it presents information about the electrical activity of the brain. Automatic Seizure...
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Dopamine and Glutamate Crosstalk Worsen the Seizure Outcome in TLE-HS Patients
Temporal lobe epilepsy (TLE), accompanied by hippocampal sclerosis (HS), is the most common form of drug-resistant epilepsy (DRE). Nearly 20% of the...
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Role of Necroptosis, a Regulated Cell Death, in Seizure and Epilepsy
Epilepsy is a chronic neurological disease that is characterized by spontaneous and recurrent seizures. Regulated cell death is a controlled process...
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Parameterized aperiodic and periodic components of single-channel EEG enables reliable seizure detection
Although it is clinically important, a reliable and economical solution to automatic seizure detection for patients at home is yet to be developed....
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Privacy-preserving multi-source semi-supervised domain adaptation for seizure prediction
Domain adaptation (DA) has been frequently used to solve the inter-patient variability problem in EEG-based seizure prediction. However, existing DA...
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Machine Learning for Epilepsy: A Comprehensive Exploration of Novel EEG and MRI Techniques for Seizure Diagnosis
PurposeThis work focuses on automated epileptic seizure diagnosis (ESD) and prediction (ESP) to clarify the expanding role of machine learning (ML)...
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Using a standalone ear-EEG device for focal-onset seizure detection
BackgroundSeizure detection is challenging outside the clinical environment due to the lack of comfortable, reliable, and practical long-term...
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Assessment of clinically actionable pharmacogenetic markers to stratify anti-seizure medications
Epilepsy treatment is challenging due to heterogeneous syndromes, different seizure types and higher inter-individual variability. Identification of...
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GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice
BackgroundTemporal lobe epilepsy (TLE) is often characterized pathologically by severe neuronal loss in the hippocampus. Phagocytic activity of...
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How May a Brief Seizure Lead to Prolonged Epileptic Amnesia?
Pure amnestic seizures are defined as self-limited episodes with isolated, anterograde memory loss and have been attributed to bilateral dysfunction...
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Seizure Rescue Therapies: Comparing Approved and Commonly Used Benzodiazepine Formulations
Acute seizure therapies given out of the hospital are important for interrupting acute repetitive and prolonged seizures and preventing...
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Augmented impulsive behavior in febrile seizure-induced mice
Febrile seizure (FS) is one of the most prevalent etiological events in childhood affecting 2–5% of children from 3 months to 5 years old. Debates on...
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Effect of dietary supplementation with Lactobacillus helveticus R0052 on seizure thresholds and antiseizure potency of sodium valproate in mice
ObjectiveBoth animal and human studies, though limited, showed that multi-strain probiotic supplementation may reduce the number of seizures and/or...
