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γ-Secretase in Alzheimer’s disease
Alzheimer’s disease (AD) is caused by synaptic and neuronal loss in the brain. One of the characteristic hallmarks of AD is senile plaques containing...
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β-Secretase as a Primary Drug Target of Alzheimer Disease: Function, Structure, and Inhibition
β-secretase (BACE1) is responsible for regulating different biological functions. Several biochemical studies reported that BACE1 enzyme plays a key...
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Presenilin/γ-Secretase in the Pathogenesis of Alzheimer’s Disease
A genetic study of familial cases of Alzheimer’s disease (AD)Alzheimer’s disease (AD) has revealed that amyloid-βAmyloid-β protein (Aβ) is an...
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The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities
Alteration of neuronal protein processing is often associated with neurological disorders and is highly dependent on cellular protein trafficking. A...
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Treating Parkinson’s Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase
Parkinson’s disease (PD) is the second most common neurodegenerative disease with motor disorders as the key clinical features. BDNF/TrkB...
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The evolved divergence of γ-secretase-susceptibility of homologous proteins Ngfrb and Nradd in zebrafish
ObjectiveNGFR/p75NTR and NRADD/NRH proteins are closely related structurally and are encoded by genes that arose from a duplication event early in...
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Targeting γ-secretase for familial Alzheimer’s disease
Familial Alzheimer’s disease (FAD) is a rare early-onset genetic form of common dementia of old age. Striking in middle age, FAD is caused by...
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Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains
Alterations in the canonical processing of Amyloid Precursor Protein generate proteoforms that contribute to the onset of Alzheimer’s Disease....
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Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression
BackgroundActivated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which...
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Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats
The objective of this study was to evaluate the combined and independent effects of exercise training and L-Arginine loaded chitosan nanoparticles...
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Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1–42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal neurodevelopment processes
The gut microbiota influences brain development and functioning through the gut-brain axis. This is first study regulate maternal gut microbiota and...
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γ-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation
We here defined the impacts of γ-secretase inhibitors (GSIs) on T-cell-dependent BCMA-specific multiple myeloma (MM) cell lysis and immunomodulatory...
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Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer’s disease-related pathologies in a senescence-accelerated mouse model
BackgroundCurrently, there is no cure for Alzheimer’s disease (AD). Therapeutics that can modify the early stage of AD are urgently needed. Recent...
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γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
Backgroundγ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two...
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Substrate-based chemical probes for Alzheimer’s γ-secretase
The membrane-embedded γ-secretase complex carries out hydrolysis within the lipid bilayer in proteolyzing nearly 100 different membrane protein...
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Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with age as a major risk factor. AD is the most common dementia with abnormal...
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Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly...
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α-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer’s disease
BackgroundThe disintegrin metalloproteinase 10 (ADAM10) is the main α-secretase acting in the non-amyloidogenic processing of APP. Some ADAM10 gene...
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Plant-Based β-Secretase (BACE-1) Inhibitors: A Mechanistic Approach to Encounter Alzheimer’s Disorder
BACE-1 (β-secretase) has emerged as a promising drug to treat Alzheimer’s disease (AD). BACE-1, an aspartic protease, acts on amyloid precursor...
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Amyloid-independent pathogenesis for Alzheimer’s disease: implications for drug design
Alzheimer’s disease (AD) is characterized pathologically by cerebral deposits of the amyloid β-peptide (Aβ), particularly the aggregation prone...
