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Scutellarin Acts via MAPKs Pathway to Promote M2 Polarization of Microglial Cells
Scutellarin, an herbal agent, is known to possess anti-oxidant and anti-inflammatory properties. In activated microglia, it has been reported that...
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Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Epithelial-mesenchymal...
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Design, synthesis of amide derivatives of scutellarin and their antileukemia and neuroprotective activities
A unique series of amide-scutellarin derivatives were designed and synthesized in order to develop the function of scutellarin further. The...
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Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK/NF-κB pathways
Alcoholic liver disease (ALD) is the most frequent liver disease worldwide, resulting in severe harm to personal health and posing a serious burden...
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Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high vascularity and frequent metastasis. Tumor-associated...
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Scutellarin is Highly Likely to be Responsible for Drug-Drug Interactions Mediated by Hepatic Organic Anion-Transporting Polypeptide1B3
PurposeScutellarin, a flavonoid derived from the plant Erigeron breviscapus, is currently widely used to treat cerebrovascular diseases,...
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Beneficial effects of flavonoids on cardiovascular diseases by influencing NLRP3 inflammasome
Cardiovascular diseases (CVDs) are a leading cause of global mortality and have a high incidence rate worldwide. The function of inflammasomes in...
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Scutellarin Exerts Anti-Inflammatory Effects in Activated Microglia/Brain Macrophage in Cerebral Ischemia and in Activated BV-2 Microglia Through Regulation of MAPKs Signaling Pathway
BackgroundScutellarin, an herbal compound, can effectively suppress the inflammatory response in activated microglia/brain macrophage(AM/BM) in...
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Hybrid molecules of scutellarein and 3, 5, 6-trimethylpyrazine-2-formic acid linked with polar amino acid for ischemic stroke
Scutellarin has been found to possess a certain protective activity against oxidative damage, and scutellarein has been proved to be the main...
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Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects
Neurodegeneration, the decline of nerve cells in the brain, is a common feature of neurodegenerative disorders (NDDs). Oxidative stress, a key factor...
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The Role of Inflammasome in Cancers and Potential Therapeutic Targets
Inflammasome is a multi-protein complex that govern the maturation of the pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 in...
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Mechanistic Static Model based Prediction of Transporter Substrate Drug-Drug Interactions Utilizing Atorvastatin and Rifampicin
ObjectiveAn in vitro relative activity factor (RAF) technique combined with mechanistic static modeling was examined to predict drug-drug...
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PK-PD Correlation of Erigeron Breviscapus Injection in the Treatment of Cerebral Ischemia-Reperfusion Injury Model Rats
By measuring the cerebral infarction rate and neurological behavioral score of rats in a sham operation group, an MCAO model control group and an Erige...
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Polyphenols Targeting MAP Kinase Signaling Pathway in Neurological Diseases: Understanding Molecular Mechanisms and Therapeutic Targets
Polyphenols are a class of secondary metabolic products found in plants that have been extensively studied for how well they regulate biological...
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The Role of mTOR in Doxorubicin-Altered Cardiac Metabolism: A Promising Therapeutic Target of Natural Compounds
Doxorubicin (DOX) is commonly used for the treatment of various types of cancer, however can cause serious side effects, including cardiotoxicity....
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Hispidulin: a promising anticancer agent and mechanistic breakthrough for targeted cancer therapy
Cancer is a complex disease characterized by dysregulated cell growth and division, posing significant challenges for effective treatment....
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Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-κB and p38/JNK pathway in LPS-induced BV-2 microglial cells
In vitro and in vivo studies indicate that scutellarin (SCU) exerts anti-inflammatory effects in the central nervous system (CNS) and inhibits...
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Flavonoid-Based Derivatives for Modulating Various Targets of Alzheimer’s Disease
Alzheimer’s disease (AD), an advanced multifactorial neurodegenerative disease mainly accompanied by cognitive impairment, is the most conversant...