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Loosely synchronized activation of anterior cingulate cortical neurons for scratching response during histamine-induced itch
Itch is a distinctive sensation that causes a specific affection and scratching reaction. The anterior cingulate cortex (ACC) has been linked to itch...
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Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments
ObjectivesAnimal models of skin disease are used to evaluate therapeutics to alleviate disease. One common clinical dermatological complaint is...
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Region-specific activation in the accumbens nucleus by itch with modified scratch efficacy in mice – a model-free multivariate analysis
Itch is a protective/defensive function with divalent motivational drives. Itch itself elicits an unpleasant experience, which triggers the urge to...
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The lateral habenula nucleus regulates pruritic sensation and emotion
Itch is a complex aversive sensory and emotional experience. As a most upsetting symptom in many dermatological and systemic diseases, it lacks...
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Hypothalamic orexinergic neurons modulate pain and itch in an opposite way: pain relief and itch exacerbation
Pain and itch are recognized as antagonistic sensations; pain suppresses itch and inhibition of pain generates itch. There is still a lack of...
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Anti-pruritic effect of L-carnitine against chloroquine-induced pruritus mediated via nitric oxide pathway
BackgroundPruritus, or itching, is a distressing symptom associated with various dermatological and systemic diseases. L-carnitine (βeta...
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Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice
Mitochondrial reactive oxygen species (mROS) that are overproduced by mitochondrial dysfunction are linked to pathological conditions including...
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Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors
Compulsive behaviors have been associated with striatal hyperactivity. Parvalbumin-positive striatal interneurons (PVIs) in the striatum play a...
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Dendritic cells under allergic condition enhance the activation of pruritogen-responsive neurons via inducing itch receptors in a co-culture study
BackgroundItch sensitization has been reported in patients with chronic allergic skin diseases and observed in a mouse model of allergic contact...
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Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1
BackgroundItch is an unpleasant sensation that can be debilitating, especially if it is chronic and of non-histaminergic origin, as treatment options...
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Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis
BackgroundClassical understanding of allergic conjunctivitis (ACJ) suggests that ocular itch results from a mast cell-dependent inflammatory process....
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Evaluation of the scabicidal effect of a single dose of fluralaner in a rabbit model of crusted scabies
Recently, scabies was included in the WHO roadmap for neglected tropical diseases 2021–2030. Till now, ivermectin is the only available oral drug...
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Ventral striatal islands of Calleja neurons control grooming in mice
The striatum comprises multiple subdivisions and neural circuits that differentially control motor output. The islands of Calleja (IC) contain...
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Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus
Atopic dermatitis (AD) is a complex and multifactorial skin disease characterized by skin inflammation and intense pruritus. There are many...
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Proteome Profile of Trigeminal Ganglion in Murine Model of Allergic Contact Dermatitis: Complement 3 Pathway Contributes to Itch and Pain Sensation
Allergic contact dermatitis (ACD) is a common inflammatory dermatosis characterized by persistent itch and pain after topical contact with reactive...
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Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion
SLL-039 ( N -cyclopropylmethyl-7α−4′-( N ’-benzoyl) amino-phenyl-6,14-endoethano-tetrahydronorthebaine) and SLL-1206 ( N -cyclopropylmethyl-7α−3′-( p -methoxy...
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GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib
Many G-protein-coupled receptor (GPCR) agonists have been studied for transactivating epidermal growth factor receptor (EGFR) signaling through...
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A neuropeptide code for itch
Itch is one of the most primal sensations, being both ubiquitous and important for the well-being of animals. For more than a century, a desire to...
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Neurons in the caudal ventrolateral medulla mediate descending pain control
Supraspinal brain regions modify nociceptive signals in response to various stressors including stimuli that elevate pain thresholds. The medulla...
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Contagious itch can be induced in humans but not in rodents
Itch contagion has been reported in human when people watch someone scratching in a video. The basic mechanism of contagious itch induced by...
