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Application of Scaffold-Free 3D Models
This chapter will provide an overview on scaffold-free 3D models focusing on aggregates, spheroids, and organoids. While often used synonymously, the...
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Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional (3D) tissue-like surrogates, capitalising upon the inherent...
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Mammalian Cell Culture in Three Dimensions: Basic Guidelines
Mammalian cell culture has technologically advanced from being conducted in two- to three-dimensional culture vessels (2D and 3D, respectively). The...
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Harnessing three-dimensional (3D) cell culture models for pulmonary infections: State of the art and future directions
Pulmonary infections have been a leading etiology of morbidity and mortality worldwide. Upper and lower respiratory tract infections have...
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Scaffold-based 3D cell culture models in cancer research
Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional...
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Changes of immune microenvironment in head and neck squamous cell carcinoma in 3D-4-culture compared to 2D-4-culture
BackgroundThe immune system plays a crucial role in initiating, progressing, and disseminating HNSCC. This study aims to investigate the differences...
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Role of three-dimensional cell culture in therapeutics and diagnostics: an updated review
Drug development and testing are a tedious and expensive process with a high degree of uncertainty in the clinical success and preclinical validation...
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Organ, Histotypic and Organotypic Culture, and Tissue Engineering
Organ, histotypic, and organotypic culture using mammalian three-dimensional (3D) cell culture technologies are the primary focus of this chapter....
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3D-Autologous Culture Method for Precision Oncology
The 3D-autologous culture method (3D-ACM) for patient-derived cancer samples utilizes a patient’s own body fluid or serum to prepare a 3D scaffold...
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Scaffold-mediated switching of lymphoma metabolism in culture
BackgroundDiffuse large B cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma (NHL) and accounts for about a third of all NHL...
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Culture and Co-culture of Cells for Multi-organ on a Chip
The pre-clinical trials in the drug discovery timeline involve an immense amount of time and money to elucidate the drug responses precisely. Cell...
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Lab Equipment for 3D Cell Culture
When starting to work with 3D cell cultures it is essential to be aware of the differences to common 2D cultures in terms of expenses and equipment...
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Deciphering the role of FUS::DDIT3 expression and tumor microenvironment in myxoid liposarcoma development
BackgroundMyxoid liposarcoma (MLS) displays a distinctive tumor microenvironment and is characterized by the FUS::DDIT3 fusion oncogene, however,...
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Exploring the interaction between extracellular matrix components in a 3D organoid disease model to replicate the pathophysiology of breast cancer
In vitro models are necessary to study the pathophysiology of the disease and the development of effective, tailored treatment methods owing to the...
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Bladder cancer: therapeutic challenges and role of 3D cell culture systems in the screening of novel cancer therapeutics
Bladder cancer (BC) is the sixth most common worldwide urologic malignancy associated with elevated morbidity and mortality rates if not well...
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Large-Scale Culture of Mammalian Cells for Various Industrial Purposes
There is the widespread use of large-scale mammalian cell culture in biotechnological and pharmaceutical industries for various purposes. Select...
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Culture of Neuron and Glia Cells
The mammalian nervous system consists of neurons that transmit the coordinated neuronal signals throughout the body and glia or supporting cells that...
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A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine
Cancer is a highly heterogeneous disease, and thus treatment responses vary greatly between patients. To improve therapy efficacy and outcome for...
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Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations
To improve the mechanistic screening of reproductive toxicants in chemical-risk assessment and drug development, we have developed a...
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Three-dimensional (3D) cell culture: a valuable step in advancing treatments for human hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the fifth most common malignant cancer and the third most frequent cause of tumour-related mortality worldwide....
