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Evaluating cancer genetic services in a safety net system: overcoming barriers for a lasting impact beyond the CHARM research project
Underserved patients face substantial barriers to receiving cancer genetic services. The Cancer Health Assessments Reaching Many (CHARM) study...
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Identifying the Needs of Primary Care Providers Caring for Breast and Colon Cancer Survivors in the Safety-Net: a Qualitative Study
As the number of cancer survivors continues to increase and given the shortage of oncology clinicians in safety net health care settings, primary...
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Implementation of an Evidence-Based Intervention with Safety Net Clinics to Improve Mammography Appointment Adherence Among Underserved Women
The Peace of Mind Program is an evidence-based intervention to improve mammography appointment adherence in underserved women. The aim of this study...
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The effect of mailed outreach on FIT completion among patients aged 45–50 in a safety net healthcare system
PurposeColorectal cancer screening is recommended starting at age 45, but there has been little research on strategies to promote screening in...
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Key Informants’ Perspectives on Implementing a Comprehensive Lung Cancer Screening Program in a Safety Net Healthcare System: Leadership, Successes, and Barriers
Implementing evidence-based practice (EBP) in a safety net healthcare system is challenging. This study examined factors associated with feasibility...
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Diverse pharmacovigilance jurisdiction—The right way for global drug safety?
PurposeThe purpose of this narrative review is to provide a comparison of several countries with different legislation and approaches to...
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Artificial Intelligence for Drug Toxicity and Safety
This chapter reviews the use of machine learning and artificial intelligence algorithms to evaluate drug safety from discovery to post-launch....
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A Science-Based Methodology Framework for the Assessment of Combination Safety Risks in Clinical Trials
Multiple components factor into the assessment of combination safety risks when two or more novel individual products are used in combination in...
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Optimizing Medication Safety for Patients at Transitions of Care
Transitions of care are vulnerable moments that put patients at high risk for medication discrepancies, adverse drug events (ADEs), and drug therapy...
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Trends in prevalence of extended-spectrum beta-lactamase-producing Escherichia coli isolated from patients with community- and healthcare-associated bacteriuria: results from 2014 to 2020 in an urban safety-net healthcare system
BackgroundThe prevalence of infections caused by extended-spectrum beta-lactamase producing Escherichia coli (ESBL- E. coli ) is increasing worldwide,...
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A prospective, randomized, phase II study to assess the schemas of retreatment with Lutathera® in patients with new progression of an intestinal, well-differentiated neuroendocrine tumor (ReLUTH)
BackgroundAlthough neuroendocrine tumors (NET) are classed as rare, they have a high prevalence and their incidence is increasing. Effective...
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Targeting inflammation in atherosclerosis — from experimental insights to the clinic
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves inflammation from its inception to the emergence of...
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Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial
The radiation-attenuated Plasmodium falciparum sporozoite (PfSPZ) vaccine provides protection against P. falciparum infection in malaria-naïve...
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The INGENIOUS trial: Impact of pharmacogenetic testing on adverse events in a pragmatic clinical trial
Adverse drug events (ADEs) account for a significant mortality, morbidity, and cost burden. Pharmacogenetic testing has the potential to reduce ADEs...
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Barriers and facilitators of Hispanic/Latino parents caregiving for a childhood cancer survivor: a qualitative study
PurposeThis qualitative study aimed to explore Hispanic parents of childhood cancer survivors (CCS) perceptions of facilitators and barriers to their...
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Deep learning in histopathology: the path to the clinic
Machine learning techniques have great potential to improve medical diagnostics, offering ways to improve accuracy, reproducibility and speed, and to...
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Natural killer cells in antitumour adoptive cell immunotherapy
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with intrinsic abilities to identify and eliminate virally...
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Therapeutics and Diagnostics Discovery
In any therapeutics discovery and development effort, multiple critical steps must be accomplished to arrive at a compound that is safe and...
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Finding the sweet spot: a qualitative study exploring patients’ acceptability of chatbots in genetic service delivery
Chatbots, web-based artificial intelligence tools that simulate human conversation, are increasingly in use to support many areas of genomic...
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Causal machine learning for predicting treatment outcomes
Causal machine learning (ML) offers flexible, data-driven methods for predicting treatment outcomes including efficacy and toxicity, thereby...
