Search
Search Results
-
Retinal nerve fibre layer thinning and corneal nerve loss in patients with Bardet-Biedl syndrome
BackgroundBardet-Biedl syndrome (BBS) is an autosomal recessive, genetically heterogeneous, pleiotropic disorder caused by variants in genes involved...
-
DEG/ENaC Ion Channels in the Function of the Nervous System: From Worm to Man
DEG/ENaC channels are voltage-independent Na+/Ca2+ channels that are conserved across species and are expressed in many different cell types and...
-
The mechanosensory neurons of touch and their mechanisms of activation
Our sense of touch emerges from an array of mechanosensory structures residing within the fabric of our skin. These tactile end organ structures...
-
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
The skin is equipped with specialized mechanoreceptors that allow the perception of the slightest brush. Indeed, some mechanoreceptors can detect...
-
Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes
Brown adipocytes expend energy via heat production and are a potential target for the prevention of obesity and related metabolic disorders. Piezo1...
-
The Somatosensory World of the African Naked Mole-Rat
The naked mole-rat (Heterocephalus glaber) is famous for its longevity and unusual physiology. This eusocial species that lives in highly ordered and...
-
Piezo channels in the urinary system
The Piezo channel family, including Piezo1 and Piezo2, includes essential mechanosensitive transduction molecules in mammals. Functioning in the...
-
The role of Piezo proteins and cellular mechanosensing in tuning the fate of transplanted stem cells
Differentiation of stem cells can be modulated by a combination of internal and external signals, including mechanical cues from the surrounding...
-
Single-cell analysis of olfactory neurogenesis and differentiation in adult humans
The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an...
-
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function
The ε4 allele of the apolipoprotein E ( APOE ) gene, a genetic risk factor for Alzheimer’s disease, is abundantly expressed in both the brain and...
-
Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis
We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS)...
-
Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
BackgroundAcid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of...
-
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic...
-
Cell Biology of Tactile Afferents
This chapter reviews our current understanding of the cellular and molecular basis of sensory transduction and neurotransmission in mammalian tactile...
-
Sensory mechanotransduction at membrane-matrix interfaces
Sensory cells specialized to detect extremely small mechanical changes are common to the auditory and somatosensory systems. It is widely accepted...
-
The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
Piezo1 and Piezo2 are critically required for nonselective cationic mechanosensitive channels in mammalian cells. Within the last 5 years, tremendous...
-
Experimental validation of predicted subcellular localizations of human proteins
BackgroundComputational methods have been widely used for the prediction of protein subcellular localization. However, these predictions are rarely...
-
Piezo channels: from structure to function
Mechanotransduction is the conversion of mechanical stimuli into biological signals. It is involved in the modulation of diverse cellular functions...
-
Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy
Nerve growth factor (NGF) is central to the development and functional regulation of sensory neurons that signal the first events that lead to pain....
-
Mechanotransduction in epidermal Merkel cells
The cellular and molecular basis of vertebrate touch reception remains least understood among the traditional five senses. Somatosensory afferents...
