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JAK-STAT signaling maintains homeostasis in T cells and macrophages
Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the...
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JAK/STAT in leukemia: a clinical update
Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of...
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Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy
Protein arginine methyltransferases (PRMTs) modulate diverse cellular processes, including stress responses. The present study explored the role of...
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STAT proteins in cancer: orchestration of metabolism
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of cancer, from tumour initiation through disease progression and...
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JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating...
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SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation
Oncolytic viruses (OVs) are emerging as a potentially useful treatment for malignancies due to the capabilities of direct oncolysis and immune...
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USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway
Hypertension is a pathological state of the metabolic syndrome that increases the risk of cardiovascular disease. Managing hypertension is...
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Endothelial Cells Promote Pseudo-islet Function Through BTC-EGFR-JAK/STAT Signaling Pathways
Interactions between cells are of fundamental importance in affecting cell function. In vivo, endothelial cells and islet cells are close to each...
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Genome-Wide Identification and Expression Analysis of the STAT Family in Reeve’s Turtle (Mauremys reevesii)
The Stat (signal transducer and activator of transcription) gene family plays a vital role in regulating immunity and the processes of cellular...
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Pretreatment with platelet-rich plasma protects against ischemia–reperfusion induced flap injury by deactivating the JAK/STAT pathway in mice
BackgroundIschemia–reperfusion (I/R) injury is a major cause of surgical skin flap compromise and organ dysfunction. Platelet-rich plasma (PRP) is an...
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Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) cascade is a pleiotropic pathway that involves...
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Roflumilast ameliorates diabetic nephropathy in rats through down-regulation of JAK/STAT signaling pathway
Roflumilast is a potent selective inhibitor of the phosphodiesterase-4 enzyme which greatly manifest an anti-inflammatory activity in chronic...
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Wogonin upregulates SOCS3 to alleviate the injury in Diabetic Nephropathy by inhibiting TLR4-mediated JAK/STAT/AIM2 signaling pathway
BackgroundDiabetic nephropathy (DN) is a life-threatening renal disease and needs urgent therapies. Wogonin is renoprotective in DN. This study aimed...
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Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer
BackgroundRNA binding motif protein 15 (RBM15), a writer of N6-methyladenosine (m6A) methylation, contributes significantly to the development of...
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Pharmacological inhibition of demethylzeylasteral on JAK-STAT signaling ameliorates vitiligo
BackgroundThe activation of CD8 + T cells and their trafficking to the skin through JAK-STAT signaling play a central role in the development of...
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Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide
BackgroundNatural killer/T-cell lymphoma (NKTL) is a rare type of aggressive and heterogeneous non-Hodgkin's lymphoma (NHL) with a poor prognosis and...
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Using Human Fetal Neural Stem Cells to Elucidate the Role of the JAK-STAT Cell Signaling Pathway in Oligodendrocyte Differentiation In Vitro
Oligodendrocytes (OL) are the myelinating cells of the central nervous system that mediate nerve conduction. Loss of oligodendrocytes results in...
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IL4I1 enhances PD-L1 expression through JAK/STAT signaling pathway in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is the major type of lung cancer and is one of the deadliest cancers worldwide. IL4I1, as a gene associated with...
