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DHA Attenuates Hypoxia/Reoxygenation Injury by Activating SSeCKS in Human Cerebrovascular Pericytes
Docosahexaenoic acid (DHA) can alleviate cerebral ischemia/reperfusion injury by reducing blood–brain barrier permeability and maintaining its...
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SSeCKS/Gravin/AKAP12 Inhibits PKCζ-Mediated Reduction of ERK5 Transactivation to Prevent Endotoxin-Induced Vascular dysfunction
SSeCKS/Gravin/AKAP12 is a protein kinase C (PKC) substrate that inhibits the activity of PKC through binding with it. SSeCKS is expressed in vascular...
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SSeCKS promoted lipopolysaccharide-sensitized astrocytes migration via increasing β-1,4-galactosyltransferase-I activity
Astrocytes migration is essential in the formation of the glial scar during the injury response process of the central nervous system (CNS)...
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Metastasis suppressor genes in clinical practice: are they druggable?
Since the identification of NM23 (now called NME1 ) as the first metastasis suppressor gene (MSG), a small number of other gene products and...
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Parietal epithelial cell dysfunction in crescentic glomerulonephritis
Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular...
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PKA Anchoring and Synaptic Tagging and Capture
Synaptic tagging and capture (STC) hypothesis has been receiving increasing attention because it reflects the heterosynaptic association of...
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The genomic regulation of metastatic dormancy
The genomics and pathways governing metastatic dormancy are critically important drivers of long-term patient survival given the considerable...
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Gastrodin: a comprehensive pharmacological review
Tianma is the dried tuber of Gastrodia elata Blume ( G. elata ), which is frequently utilized in clinical practice as a traditional Chinese medicine....
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Nucleic Acids as Novel Therapeutic Modalities to Address Multiple Sclerosis Onset and Progression
The issue of treating Multiple Sclerosis (MS) begins with disease-modifying treatments (DMTs) which may cause lymphopenia, dyspnea, and many other...
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Rethinking the biology of metastatic melanoma: a holistic approach
Over the past decades, melanoma-related mortality has remained nearly stable. The main reason is treatment failure of metastatic disease and the...
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Expression of FGD4 positively correlates with the aggressive phenotype of prostate cancer
BackgroundFGD4 (Frabin) is an F-actin binding protein with GTP/GDP exchange activity specific for CDC42. It is involved in reorganization of the...
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Structure and Function of the Blood–Brain Barrier (BBB)
The blood-brain barrier (BBB) protects the vertebrate central nervous system from harmful blood-borne, endogenous and exogenous substances to ensure...
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EACR-MRS conference on Seed and Soil: In Vivo Models of Metastasis
New experimental tools are urgently required to better understand the metastatic process. The importance of such tools is underscored by the fact...
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Parietal cells—new perspectives in glomerular disease
In normal glomeruli, parietal epithelial cells (PECs) line the inside of Bowman’s capsule and form an inconspicuous sheet of flat epithelial cells in...
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Function to Failure: Compartmentalization of Cardiomyocyte Signaling by A-Kinase-Anchoring Proteins
Compartmentalization of signaling enzymes allows cardiomyocytes to make contextually specific decisions using a common set of second messengers....
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Increased SSeCKS Expression in Rat Hepatic Stellate Cells Upon Activation In Vitro and In Vivo
Recent reports suggest that src suppressed c kinase substrates (SSeCKS) are early inflammatory response protein. However, there is only scarce...
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Expression of Src Suppressed C Kinase Substrate in Rat Neural Tissues During Inflammation
Src-suppressed C kinase substrate (SSeCKS), an in vivo and in vitro protein kinase C substrate, is a major lipopolysaccharide (LPS) response protein...
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Glial regulation of the blood-brain barrier in health and disease
The brain is the organ with the highest metabolic demand in the body. Therefore, it needs specialized vasculature to provide it with the necessary...
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