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SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation
Neuroinflammation and microglial activation are involved in the pathogenesis of sepsis-associated encephalopathy (SAE). Mitochondrial dynamics...
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SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice
BackgroundNeuroinflammation is crucial in the development of postoperative cognitive dysfunction (POCD), and microglial activation is an active...
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Liposome Nanocarriers for Peptide Drug Delivery
Peptide drugs have limitations, including low membrane permeability, inability to cross the blood-brain barrier, low stability towards enzymatic...
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Step by Step Toward an Amyloid Beta Peptide-Based Hypothesis of Alzheimer’s Disease
Following the Alzheimer’s research decisive year 1987, the compass was set toward further exploration of the Amyloid–Alzheimer’s link. A great amount...
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Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Clinical Pharmacokinetics
The calcitonin gene-related peptide transmission was the target for recent development of drugs that effectively prevent attacks of both episodic and...
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Potential of oligonucleotide- and protein/peptide-based therapeutics in the management of toxicant/stressor-induced diseases
Exposure to toxicants/stressors has been linked to the development of many human diseases. They could affect various cellular components, such as...
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Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer’s Disease
Neuroprotective peptides are promising candidate molecules for the treatment of Alzheimer’s disease (AD). Oral application of KED (Lys-Glu-Asp)...
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Emerging Protein and Peptide-Based Nanomaterials for Cancer Therapeutics
Delivering small- or large-sized cancer therapeutics precisely to the disease site by employing various nanocarriers is a fast-evolving area in...
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IMGT/3Dstructure-DB: T-Cell Receptor TR Paratope and Peptide/Major Histocompatibility pMH Contact Sites and Epitope
T-cell receptors (TR), the antigen receptors of T cells, specifically recognize peptides presented by the major histocompatibility (MH) proteins, as...
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Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization
Spinal cord injury (SCI) is a devastating injury that may result in permanent motor impairment. The active ingredients of medications are unable to...
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Formyl peptide receptors in the mucosal immune system
Formyl peptide receptors (FPRs) belong to the G protein-coupled receptor (GPCR) family and are well known as chemotactic receptors and pattern...
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Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment
Metastasis is one of the main reasons causing death in cancer patients. It was reported that chemotherapy might induce metastasis. In order to...
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In Vitro Evaluation and Biodistribution Studies of HPMA Copolymers Targeting the Gastrin Releasing Peptide Receptor in Prostate CancerPurposeThe development of diagnostic and therapeutic agents utilizing small peptides (e.g., bombesin (BBN)) to target the overexpression of the...
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Reversible stabilization of DNA/PEI complexes by reducible click-linkage between DNA and polymer. A new polyplex concept for lowering polymer quantity
Nonviral transfection of mammalian cells can be performed with electrostatic complexes (polyplexes) between a plasmid DNA (pDNA) encoding a foreign...
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Abatement of the binding of human hexokinase II enzyme monomers by in-silico method with the design of inhibitory peptides
The hexokinase II enzyme is bound to the (VDAC1) channel in the form of a dimer and prevents the release of cell death factors from mitochondria to...
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Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients
BackgroundAs leading contributors to worldwide morbidity and mortality, sepsis and septic shock are considered a major global health concern....
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Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses
Endothelial cells (ECs) are constantly submitted in vivo to hemodynamical forces derived from the blood circulation, including shear stress (SS). ECs...
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Microorganisms in Pathogenesis and Management of Sjögren’s Syndrome
Sjögren’s syndrome (SS) is an autoimmune disease characterized by mononuclear cell infiltration of exocrine glands, leading to loss of function and...
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Transferrin Receptor Targeted Cellular Delivery of Doxorubicin Via a Reduction-Responsive Peptide-Drug Conjugate
PurposeTransferrin receptors (TfRs) are overexpressed in tumor cells but are scarce in normal tissues, which makes TfR an attractive target for drug...
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Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial
Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy. Afamitresgene autoleucel (afami-cel) is a human leukocyte...
