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Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development
The communication between tumor cells and tumor microenvironment plays a critical role in cancer development. Cancer-associated fibroblasts (CAFs)...
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MeCP2 inhibits ischemic neuronal injury by enhancing methylation of the FOXO3a promoter to repress the SPRY2-ZEB1 axis
Methyl CpG binding protein 2 (MeCP2) is involved in nerve regeneration following ischemic stroke, but the related mechanism remains unclear. Here, we...
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Retinoblastoma gene expression profiling based on bioinformatics analysis
BackgroundRetinoblastoma (RB) is frequently occurring malignant tumors that originate in the retina, and their exact cause and development mechanisms...
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Retraction Note: Knockdown of FOXO3a induces epithelialmesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the βcatenin/TCF4 pathway through SPRY2
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1046-x.
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Sprouty2 Inhibits Migration and Invasion of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Down-regulating ATF2 Expression and Phosphorylation
Activating transcription factor 2(ATF2), a transcription factor belonging to the AP-1 family, plays an important role in inflammation. However, its...
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RETRACTED ARTICLE: Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2
BackgroundEarly invasion and metastasis are responsible for the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC), and...
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Therapeutic effect and transcriptome-methylome characteristics of METTL3 inhibition in liver hepatocellular carcinoma
Methyltransferase-like 3 (METTL3) is the key subunit of methyltransferase complex responsible for catalyzing N6-methyladenosine (m 6 A) modification on...
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Identification and gene expression profiling of human gonadotrophic pituitary adenoma stem cells
BackgroundGonadotrophic pituitary adenoma is a major subtype of pituitary adenoma in the sellar region, but it is rarely involved in the...
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Hydrodynamic Transfection of Hepatocytes for the Study of Hepatocellular Carcinogenesis
Hydrodynamic tail vein injection (HTVi), also called hydrodynamic gene transfer (HGT), is attracting increasing interest for modeling hepatic...
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Harm of circadian misalignment to the hearts of the adolescent wistar rats
PurposeThe purpose of this study was to observe the harm of circadian misalignment (CM), caused by an inverted photoperiod (IP), on the hearts of the...
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Expanding the clinical-pathological and genetic spectrum of RYR1-related congenital myopathies with cores and minicores: an Italian population study
Mutations in the RYR1 gene, encoding ryanodine receptor 1 (RyR1), are a well-known cause of Central Core Disease (CCD) and Multi-minicore Disease...
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Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors
The mammalian cochlea detects and transduces auditory stimuli in the environment through sensory hair cells (HCs). Unlike non-mammalian species,...
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CaV1.1 Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies
In skeletal muscle, excitation–contraction (EC) coupling relies on the mechanical coupling between two ion channels: the L-type voltage-gated calcium...
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miRNAs in pancreatic cancer progression and metastasis
Small non-coding RNA or microRNA (miRNA) are critical regulators of eukaryotic cells. Dysregulation of miRNA expression and function has been linked...
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How metformin affects various malignancies by means of microRNAs: a brief review
Metformin known as the first-line orally prescribed drug for lowering blood glucose in type II diabetes (T2DM) has recently found various therapeutic...
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Molecular Mechanisms of Metal-Induced Carcinogenesis
Occupational and environmental exposures to metals are strongly associated with an increased risk of various cancers. Although carcinogenesis caused...
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Therapeutic Potential of MicroRNAs and Their Nanoparticle-based Delivery in the Treatment of Liver Fibrosis
Chronic liver disease is a global health problem owing to its high morbidity and the limited available treatment options. Liver fibrosis, the most...
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Ring Chromosome 13
Ring chromosome 13 (RC13) is detected using karyoty**, fluorescence in situ hybridization (FISH), and chromosome microarray analysis (CMA) to...
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Targeting miR-21 in spinal cord injuries: a game-changer?
Spinal cord injury (SCI) is a devastating neurological state causing physical disability, psychological stress and financial burden. SCI global rate...
