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Spad value varies with age and leaf of maize plant and its relationship with grain yield
ObjectivesA field experiment was conducted to evaluate Soil Plant Analysis Development (SPAD) value in different age and leaf of maize hybrid and...
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Antibioflm effects of extracellular matrix degradative agents on the biofilm of different strains of multi-drug resistant Corynebacterium striatum
BackgroundCorynebacterium striatum is a microorganism with an excellent capacity for biofilm production and thus has been correlated with nosocomial...
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Stability of housekee** genes in inflamed joints of spontaneous and collagen-induced arthritis in DBA/1 mice
BackgroundDBA/1 mice arthritis models have contributed to our understanding of human rheumatoid arthritis (RA) and spondyloarthritis (SpA)...
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Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob disease
BackgroundBlood neurofilament light (Nfl) and total-tau (t-tau) have been described to be increased in several neurological conditions, including...
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Immunoglobulin Replacement Therapy Versus Antibiotic Prophylaxis as Treatment for Incomplete Primary Antibody Deficiency
BackgroundPatients with an IgG subclass deficiency (IgSD) ± specific polysaccharide antibody deficiency (SPAD) often present with recurrent...
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Immune Responses 6 Months After mRNA-1273 COVID-19 Vaccination and the Effect of a Third Vaccination in Patients with Inborn Errors of Immunity
PurposePatients with inborn errors of immunity (IEI) are at increased risk of severe coronavirus disease-2019 (COVID-19). Effective long-term...
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Clinical Validation of a Primary Antibody Deficiency Screening Algorithm for Primary Care
PurposeThe diagnostic delay of primary antibody deficiencies (PADs) is associated with increased morbidity, mortality, and healthcare costs....
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Artificial Neural Network (ANN)-Based Determination of Fractional Contributions from Mixed Fluorophores using Fluorescence Lifetime Measurements
Here we present an artificial neural network (ANN)-approach to determine the fractional contributions P i from fluorophores to a multi-exponential...
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Molecular characterization and whole-genome sequencing of Corynebacterium diphtheriae causing skin lesion
We present a case of skin lesion caused by nontoxigenic Corynebacterium diphtheriae . Genomic taxonomy analyses corroborated the preliminary...
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Plasma Lipocalin 2 in Alzheimer’s disease: potential utility in the differential diagnosis and relationship with other biomarkers
BackgroundLipocalin-2 is a glycoprotein that is involved in various physiological and pathophysiological processes. In the brain, it is expressed in...
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Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer’s disease
BackgroundHigh-density oligomers of the prion protein (HDPs) have previously been identified in brain tissues of patients with rapidly progressive...
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Impact of JAK Inhibitors in Pediatric Patients with STAT1 Gain of Function (GOF) Mutations—10 Children and Review of the Literature
IntroductionSince the first description of gain of function (GOF) mutations in signal transducer and activator of transcription (STAT) 1, more than...
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Noninvasive Visualization of Amyloid-Beta Deposits in Alzheimer’s Amyloidosis Mice via Fluorescence Molecular Tomography Using Contrast Agent
Alzheimer’s disease is pathologically featured by the accumulation of amyloid-beta (Aβ) plaque and neurofibrillary tangles. Compared to small animal... -
Distinct nuclear compartment-associated genome architecture in the develo** mammalian brain
Nuclear compartments are thought to play a role in three-dimensional genome organization and gene expression. In mammalian brain, the architecture...
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Phylogenomic analyses of multidrug resistant Corynebacterium striatum strains isolated from patients in a tertiary care hospital in the UK
Corynebacterium striatum is an emerging nosocomial pathogen. This is the first report showing the presence of three distinct multidrug resistant...
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Use of extracorporeal membrane oxygenation in massive amlodipine overdose
Calcium-channel blocker overdose can result in profound vasoplegia and cardiogenic shock, which can quickly spiral into multi-organ failure and...
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Challenges and opportunities in animal models of psoriatic arthritis
ObjectiveTo review the preparation, characteristics and research progress of different PsA animal models.
MethodsComputerized searches were...
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Harnessing clonal gametes in hybrid crops to engineer polyploid genomes
Heterosis boosts crop yield; however, harnessing additional progressive heterosis in polyploids is challenging for breeders. We bioengineered a...