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Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion in cancer metastasis. However, in lung cancer...
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STUB1-SMYD2 Axis Regulates Drug Resistance in Glioma cells
SET and MYND domain-containing protein 2 (SMYD2) is an important epigenetic regulator that methylates histone and non-histone proteins. The study...
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Targeting SMYD2 inhibits angiogenesis and increases the efficiency of apatinib by suppressing EGFL7 in colorectal cancer
Angiogenesis is an essential factor affecting the occurrence and development of solid tumors. SET And MYND Domain Containing 2 (SMYD2) serves as an...
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LINC01605, regulated by the EP300-SMYD2 complex, potentiates the binding between METTL3 and SPTBN2 in colorectal cancer
BackgroundColorectal cancer (CC) is one of the major contributors to tumor-related death worldwide, and its main cause of death is distant...
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The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias
AbstractThe five membered
S ET andM YNDD omain-containing lysine methyltransferase (SMYD) family plays pivotal roles in development and...
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Histone methyltransferase SMYD2: ubiquitous regulator of disease
SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-DEAF1) domain-containing protein 2 (SMYD2) is a protein...
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Role of Histone Methylation in Cancer: Pathobiology & Therapeutics
Cancer is among the most common causes of death in the world. Despite the recent breakthroughs over the last few decades, further research studies...
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Role of Histone Methylation in Cancer: Pathobiology and Therapeutics
Cancer is among the most common causes of death in the world. Despite the recent breakthroughs over the last few decades, further research studies...
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Epigenetics
Epigenetics is the study of heritable changes to the genome and gene expression patterns that are not caused by direct changes to the DNA sequence....
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APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells
BackgroundAberrant WNT/β-catenin signaling drives carcinogenesis. Tankyrases poly(ADP-ribosyl)ate and destabilize AXINs, β-catenin repressors....
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SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells
BackgroundAbdominal aortic aneurysm (AAA) is a deadly cardiovascular disease characterised by the gradual, irreversible dilation of the abdominal...
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Post-translational modifications on the retinoblastoma protein
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour...
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Epigenetic Alterations as an Adaptive Response to Chemotherapy
The growing field of cancer research has revealed the complex interaction between epigenetic modifications and the development of drug resistance in...
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DNA Methylation in Aortic Aneurysms of Different Localizations
Abstract—Aortic aneurysm (AA) is a life-threatening condition, and aortic rupture that is the complication of AA in the absence of emergency surgery...
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Hydrogen Sulfide can Scavenge Free Radicals to Improve Spinal Cord Injury by Inhibiting the p38MAPK/mTOR/NF-κB Signaling Pathway
Spinal cord injury (SCI) causes irreversible cell loss and neurological dysfunctions. Presently, there is no an effective clinical treatment for SCI....
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Proteomic characterization of post-translational modifications in drug discovery
Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed, are major regulators of protein activity and involved in...
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STAT3 pathway as a molecular target for resveratrol in breast cancer treatment
Signal transducer and activator of transcription 3 (STAT3) induces breast cancer malignancy. Recent clinical and preclinical studies have...
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Tumor-suppressive functions of protein lysine methyltransferases
Protein lysine methyltransferases (PKMTs) play crucial roles in histone and nonhistone modifications, and their dysregulation has been linked to the...
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Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease
Protein lysine methylation is a crucial post-translational modification that regulates the functions of both histone and non-histone proteins....
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Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities
The tumor immune microenvironment represents a sophisticated ecosystem where various immune cell subtypes communicate with cancer cells and stromal...
