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LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
BackgroundMetastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer malignancy. Long...
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SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling
BackgroundSLCO4A1-AS1 was found to be upregulated in several cancer types, including colorectal cancer (CRC). However, the detailed roles of...
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Emerging role of non-coding RNAs in the regulation of KRAS
The Kirsten ras oncogene KRAS is a member of the small GTPase superfamily participating in the RAS/MAPK pathway. A single amino acid substitution in KRAS...
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LncRNA SLCO4A1-AS1 facilitates growth and metastasis of colorectal cancer through β-catenin-dependent Wnt pathway
BackgroundEmerging evidence has shown long noncoding RNAs (lncRNAs) exert important roles in colorectal cancer (CRC) tumorigenesis. However, most...
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KRAS-related long noncoding RNAs in human cancers
KRAS is one of the most widely prevalent proto-oncogenes in human cancers. The constitutively active KRAS oncoprotein contributes to both tumor onset...
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Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview
Colorectal cancer (CRC) is the second most common cause of cancer mortality and a major health challenge worldwide. Despite advances in therapeutic...
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Transcriptome profiling and co-expression network analysis of lncRNAs and mRNAs in colorectal cancer by RNA sequencing
BackgroundLong non-coding RNAs (lncRNAs ) are widely involved in the pathogenesis of cancers. However, biological roles of lncRNAs in occurrence and...
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Interaction of lncRNAs with mTOR in colorectal cancer: a systematic review
Colorectal cancer (CRC) is the third most widespread cancer and the fourth leading lethal disease among different societies. It is thought that CRC...
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The regulatory role of antisense lncRNAs in cancer
Antisense long non-coding RNAs (antisense lncRNAs), transcribed from the opposite strand of genes with either protein coding or non-coding function,...
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Tumor Microenvironment: Multiway Role in Drug Resistance
The tumor microenvironment (TME) is an ecosystem that surrounds a tumor inside the body. TME contains a complex and dynamic system that consists of...
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Investigating the in vitro steatotic mixture effects of similarly and dissimilarly acting test compounds using an adverse outcome pathway-based approach
Within the EuroMix project, we have previously developed an adverse outcome pathway (AOP)-based in vitro assay toolbox to investigate the combined...
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A review on the role of cyclin dependent kinases in cancers
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly...
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An Integrative Bioinformatics Analysis of Microarray Data for Identifying Differentially Expressed Genes in Preeclampsia
AbstractPreeclampsia is a pregnancy-specific disorder that is characterized by hypertension and proteinuria, leading tomaternal and fetal morbidity...
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Revelation of Pivotal Genes Pertinent to Alzheimer’s Pathogenesis: A Methodical Evaluation of 32 GEO Datasets
Alzheimer’s disease (AD), a dreadful neurodegenerative disorder that affects cognitive and behavioral function in geriatric populations, is...
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Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
The solute carrier (SLC) superfamily encompasses a large variety of membrane-bound transporters required to transport a diverse array of substrates...
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LncRNA & Wnt signaling in colorectal cancer
The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs ( lncRNAs...
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Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle
BackgroundLong non-coding RNAs (lncRNAs) are important regulators of various biological and pathological processes, in particular the inflammatory...
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Epithelial–Mesenchymal Transition and Cancer Stem Cells
Epithelial–mesenchymal transition (EMT), a cellular phenotypic change from epithelial to mesenchymal-like features, is related to the resistance and...
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Different Culture Conditions Affect Drug Transporter Gene Expression, Ultrastructure, and Permeability of Primary Human Nasal Epithelial Cells
PurposeThis study aimed to characterize a commercially available primary human nasal epithelial cell culture and its gene expression of a wide range...
