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The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties and tumorigenesis in HCC
Accumulating evidence indicated that HHEX participated in the initiation and development of several cancers, but the potential roles and mechanisms...
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Nitrergic and Purinergic Nerves in the Small Intestinal Myenteric Plexus and Circular Muscle of Mice and Guinea Pigs
ATP is an excitatory and inhibitory neurotransmitter, while nitric oxide (NO) is an inhibitory neurotransmitter in the enteric nervous system (ENS)....
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Amino Acid Transporters Proteins Involved in the Glutamate-Glutamine Cycle and Their Alterations in Murine Models of Alzheimer’s Disease
The brain’s ability to integrate external stimuli and generate responses is highly complex. While these mechanisms are not completely understood,...
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Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response
Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs cellular shape and function changes throughout tissue...
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Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
BackgroundSeasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes...
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Etidronate attenuates tactile allodynia by spinal ATP release inhibition in mice with partial sciatic nerve ligation
Etidronate is widely used as a therapeutic agent for osteoporosis. We have recently shown that intrathecal administration of etidronate into mice...
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María Teresa Miras Portugal: a pioneer for vesicular nucleotide storage
Chromaffin granules are secretory granules present in adrenal medulla chromaffin cells. They contain high contents of catecholamines and nucleotides...
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The synergism of cytosolic acidosis and reduced NAD+/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis
BackgroundDuring sepsis, serve vascular dysfunctions lead to life-threatening multiple organ failure, due to vascular smooth muscle cells (VSMC)...
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Development of Purinergic Receptor Agonists and Antagonists
Adenosine, P2Y, and P2X receptors have been the focus of purinergic ligand development in the pharmaceutical sector and academic medicinal chemistry...
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Quinacrine is not a vital fluorescent probe for vesicular ATP storage
Quinacrine, a fluorescent amphipathic amine, has been used as a vital fluorescent probe to visualize vesicular storage of ATP in the field of...
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Mechanisms of ATP release in pain: role of pannexin and connexin channels
Pain is a physiological response to bodily damage and serves as a warning of potential threat. Pain can also transform from an acute response to...
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Identification and functional analysis of LncRNA-XIST ceRNA network in prostate cancer
BackgroundLong non-coding RNAs (lncRNAs) play a functional role in the progression of prostate cancer (PCa). However, the molecular mechanism,...
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COSMIC-based mutation database enhances identification efficiency of HLA-I immunopeptidome
BackgroundNeoantigens have emerged as a promising area of focus in tumor immunotherapy, with several established strategies aiming to enhance their...
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Genome-wide DNA methylation status of Mongolians exhibits signs of cellular stress response related to their nomadic lifestyle
BackgroundEpigenetics is crucial for connecting environmental stresses with physiological responses in humans. Mongolia, where nomadic livestock...
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Selection-driven adaptation to the extreme Antarctic environment in the Emperor penguin
The eco-evolutionary history of penguins is characterised by shifting from temperate to cold environments. Breeding in Antarctica, the Emperor...
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Purinergic signalling in spinal pain processing
Purinergic signalling plays important roles in somatosensory and nociceptive transmission in the dorsal horn of the spinal cord under physiological...
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The multiple de novo copy number variant (MdnCNV) phenomenon presents with peri-zygotic DNA mutational signatures and multilocus pathogenic variation
BackgroundThe multiple de novo copy number variant (M dn CNV) phenotype is described by having four or more constitutional de novo CNVs ( dn CNVs)...
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DNA methylome in pancreatic cancer identified novel promoter hyper-methylation in NPY and FAIM2 genes associated with poor prognosis in Indian patient cohort
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the leading cancers worldwide and has a poor survival, with a 5-year survival rate of...
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The preference for sugar over sweetener depends on a gut sensor cell
Guided by gut sensory cues, humans and animals prefer nutritive sugars over non-caloric sweeteners, but how the gut steers such preferences remains...
