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Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer
Dysregulation of cellular metabolism is a hallmark of breast cancer progression and is associated with metastasis and therapeutic resistance. Here,...
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Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer
BackgroundBreast cancer is a leading cause of cancer-related death for women in the USA. Thus, there is an increasing need to investigate novel...
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Identification and validation of methylated PENK gene for early detection of bladder cancer using urine DNA
BackgroundEarly detection of bladder cancer (BCa) offers patients a favorable outcome and avoids the need for cystectomy. Development of an accurate...
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Transcriptome Changes in Retinal Pigment Epithelium Post-PNU-282987 Treatment Associated with Adult Retinal Neurogenesis in Mice
PNU-282987, a selective alpha7 nicotinic acetylcholine receptor agonist, has previously been shown to have both neurogenic and broad regenerative...
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Comparison of the detectability of hot lesions on bone SPECT using six state-of-the-art SPECT/CT systems: a multicenter phantom study to optimize reconstruction parameters
Single-photon emission computed tomography with X-ray computed tomography (SPECT/CT) systems have diversified due to the remarkable developments made...
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DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity
BackgroundEpigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylation patterns have...
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Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress
BackgroundMutations in genes associated with homologous recombination (HR) increase an individual’s risk of develo** triple-negative breast cancer...
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Noncovalent SUMO-interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication
BackgroundHIV integrase (IN) and its cellular cofactors, including lens-epithelium-derived growth factor (LEDGF/p75), Ku70, p300, and Rad52, are...
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Tumor microenvironment deconvolution identifies cell-type-independent aberrant DNA methylation and gene expression in prostate cancer
BackgroundAmong men, prostate cancer (PCa) is the second most common cancer and the second leading cause of cancer death. Etiologic factors...
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Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis
BackgroundPregnancy in women with multiple sclerosis (wwMS) is associated with a reduction of long-term disability progression. The mechanism that...
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across...
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Detectability of cold tumors by xSPECT bone technology compared with hot tumors: a supine phantom study
Detecting cold as well as hot tumors is vital for interpreting bone tumors on single-photon emission computed tomography (SPECT) images. This study...
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Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling
The dysregulation of pro- and anti-inflammatory processes in the brain has been linked to the pathogenesis of major depressive disorder (MDD),...
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Stability and Structure of Adaptive Self-organized Supramolecular Artificial Water Channels in Lipid Bilayers
Nanopores that efficiently and selectively transport water have been intensively studied at the nanoscale level. A key challenge relates to linking...
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ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
BackgroundColorectal cancer (CRC) is one of the most common cancers worldwide; it is the fourth leading cause of death in the world and the third in...
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Accelerating Molecular Dynamics Simulations for Drug Discovery
Accurate prediction of ligand binding thermodynamics and kinetics is crucial in drug design. However, it remains challenging for conventional...
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Novel insights into mutual regulation between N6-methyladenosine modification and LncRNAs in tumors
N 6 -methyladenosine (m 6 A), one of the most common RNA methylation modifications, has emerged in recent years as a new layer of the regulatory...
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Development of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection
BackgroundBacterial meningitis is a life-threatening disease that occurs when pathogens such as Neisseria meningitidis cross the meningeal blood...
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SCAPP: an algorithm for improved plasmid assembly in metagenomes
BackgroundMetagenomic sequencing has led to the identification and assembly of many new bacterial genome sequences. These bacteria often contain...
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Partial trisomy 21 with or without highly restricted Down syndrome critical region (HR-DSCR): report of two new cases and reanalysis of the genotype–phenotype association
BackgroundDown syndrome (DS) is caused by the presence of an extra copy of full or partial human chromosome 21 (Hsa21). Partial (segmental) trisomy...
