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F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway
BackgroundSkin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The latency-associated peptide...
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Porous Se@SiO2 nanospheres alleviate diabetic retinopathy by inhibiting excess lipid peroxidation and inflammation
BackgroundLipid peroxidation is a characteristic metabolic manifestation of diabetic retinopathy (DR) that causes inflammation, eventually leading to...
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Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts
The TGF signaling pathway is a key regulator of cancer progression. In this work, we report for the first time the antitumor activity of TβRII-SE/Fc,...
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Applications of Block Copolymers as Stimuli-Responsive Copolymers
Stimuli-responsive polymers (smart polymers) are macromolecules that change their physicochemical properties in response to specific triggers from...
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Role of Co-Block Polymers in the Treatment of Neurodegenerative Diseases
The blood–brain barrier and the quick medication clearance into blood circulation following the administration of standard dosage form place...
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Efficacy of Corsi Block Tap** Task training for improving visuospatial skills: a non-randomized two-group study
Even though impaired visuospatial abilities can negatively affect daily functioning, there are very few training programs that attempt to improve...
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Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner
BackgroundIschemic stroke still ranks as the most fatal disease worldwide. Blood-brain barrier (BBB) is a promising therapeutic target for...
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Investigation of Molecular Diffusion at Block Copolymer Thin Films Using Maximum Entropy Method-Based Fluorescence Correlation Spectroscopy and Single Molecule Tracking
Fluorescence correlation spectroscopy (FCS) has been widely used to investigate molecular diffusion behavior in various samples. The use of the...
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In vitro interaction of polyethylene glycol-block-poly(D,L-lactide) nanocapsule devices with host cardiomyoblasts and Trypanosoma cruzi-infective forms
Chagas disease, caused by the protozoan Trypanosoma cruzi , is an important public health problem in Latin America. Nanoencapsulation of anti- T. cruzi ...
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Philosophical Perspectives on Neuroendocrine–Immune Interactions: The Building Block Model and Complementary Neuro-Endocrine-Immune-Microbiota Systems Approaches
The study of the interactions between the neuroendocrine and immune systems is a highly interdisciplinary research endeavor, in which the boundaries...
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Stellate Ganglion Block Improves the Proliferation and Function of Splenic CD4 + T Cells Through Inhibition of Posthemorrhagic Shock Mesenteric Lymph–Mediated Autophagy
Severe hemorrhagic shock leads to excessive inflammation and immune dysfunction, which results in high mortality related to mesenteric lymph return....
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Automatic skin lesion classification using a new densely connected convolutional network with an SF module
AbstractThe automatic classification of skin lesions in dermoscopy images remains challenging due to the morphological diversity of skin lesions, the...
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Host range of strand-biased circularizing integrative elements: a new class of mobile DNA elements nesting in Gammaproteobacteria
BackgroundThe strand-biased circularizing integrative elements (SEs) are putatively non-mobilizable integrative elements for transmitting...
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Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective
Status epilepticus (SE) in humans is characterized by prolonged convulsive seizures that are generalized and often difficult to control. The current...
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Development of lactoferrin-coated multifunctional copolymer micelles to cross the blood-brain barrier
The blood-brain barrier (BBB) prevents pathogens and toxins in the bloodstream from reaching the brain, but also inhibits the delivery of agents...
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MSHANet: a multi-scale residual network with hybrid attention for motor imagery EEG decoding
EEG decoding plays a crucial role in the development of motor imagery brain-computer interface. Deep learning has great potential to automatically...
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Dynamic effects of miR-20a-5p on hippocampal ripple energy after status epilepticus in rats
To determine the dynamic effects of miR-20a-5p on hippocampal ripple energy in rats after status epilepticus (SE). A lithium pilocarpine...
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Disrupted in Schizophrenia 1 Reverse Ectopic Migration of Neural Precursors in Mouse Hilus After Pilocarpine-Induced Status Epilepticus
Neural precursors in the subgranular zone (SGZ) can be stimulated by status epilepticus (SE) and ectopically migrate to the hilus. These mislocated...
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Selenium Nanoparticles as Neuroprotective Agents: Insights into Molecular Mechanisms for Parkinson’s Disease Treatment
AbstractOxidative stress and the accumulation of misfolded proteins in the brain are the main causes of Parkinson’s disease (PD). Several...
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β1- and β1/β2-adrenergic receptor antagonists block 6-nitrodopamine-induced contractions of the rat isolated epididymal vas deferens
6-Nitrodopamine (6-ND) is an endogenous modulator of the contractility in the rat isolated epididymal vas deferens (RIEVD) and considered to be the...
