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Gantenerumab: an anti-amyloid monoclonal antibody with potential disease-modifying effects in early Alzheimer’s disease
BackgroundThis review describes the research and development process of gantenerumab, a fully human anti-amyloid monoclonal antibody in development...
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Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer’s disease: a PET substudy interim analysis
BackgroundWe previously investigated low doses (105 or 225 mg) of gantenerumab, a fully human monoclonal antibody that binds and removes aggregated...
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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Many drugs that target amyloid-β (Aβ) in Alzheimer disease (AD) have failed to demonstrate clinical efficacy. However, four anti-Aβ antibodies have...
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The overlooked bacterial pandemic
The COVID-19 pandemic had a significant economic and health impact worldwide. It also reinforced the misperception that only viruses can pose a...
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Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval
The body of evidence suggesting a causative, initiating role of beta amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (AD) is substantial....
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Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer’s Disease
Two monoclonal antibodies (mAbs), aducanumab and lecanemab, have received accelerated approval from the US FDA for initiation of treatment in early...
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Medicinal Plants and their Contribution in Socio-Economic Upliftment of the Household in Gurez Valley (J&K)]
Gurez is situated along the Kishanganga river in Kashmir valley. It is remotely located but the most beautiful valley. Owing to connectivity...
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What Life May Be
In 1894, his magnum opus behind him, Bateson went on a collecting trip with the wealthy Christiana Herringham, who was grieving the death of a child....
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A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease
BackgroundGantenerumab is a fully human monoclonal antibody that binds aggregated amyloid-β (Aβ) and removes Aβ plaques by Fc receptor-mediated...
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Letter B
Baader’s syndrome see Stevens-Johnson syndrome
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Reorientation and Controversy (1895–1899)
After the publication of Materials, Bateson remained very much in Materials mode as a “naturalist” collecting insect and plant specimens. It was from...
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1977–9. The First Outbreak of Whoo** Cough
The very first cases of whoo** cough in Keyworth started in August 1977, but I was unaware of them until several weeks had passed. Even then they...
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Nanomaterials at the Biological Interphase: Protein Corona Formation and Infusion Reactions
The interactions between nanoparticles and macromolecules forming protein corona (PC) introduce new applications and challenges to the nanoparticles...
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A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 3: Heat and cold tolerance during exercise
In this third installment of our four-part historical series, we evaluate contributions that shaped our understanding of heat and cold stress during...
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What caused encephalitis lethargica?
As you can see, we are still in the field of hypothesis. Perhaps the etiologic problem of lethargica (as with many other diseases with unknown...
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Neuroprotection in Alzheimer Disease
Alzheimer’s disease (AD) is a progressive degenerative disorder of the brain that begins with memory impairment and eventually progresses to...
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The nature of acute encephalitis lethargica
Some epidemic diseases, according to still mysterious laws, after they have wrought damage with an extravagant symptomatology, slumber for years,...
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Immunotherapy for Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder in which memory and cognitive dysfunctions are the earliest symptoms....
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The psychiatry of encephalitis lethargica
An entirely new outlook for psychiatry and neurology has been opened, new research possibilities which, it is to be hoped, will bring us closer to...
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