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Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery
Achieving efficacious systemic levels of orally administered peptides is incredibly challenging due to the significant barriers to their...
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Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease that can progress to end-stage...
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GLP-1 Receptor Agonist Exposures Are Increasingly Common and Generally Associated with Mild Symptoms: A Single Poison Center Experience
IntroductionGlucagon-like peptide-1 receptor agonist use has increased over the last decade for glycemic control in type 2 diabetes mellitus,...
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SNAC for Enhanced Oral Bioavailability: An Updated Review
The delivery of proteins and peptides via an oral route poses numerous challenges to improve the oral bioavailability and patient compliance. To...
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Therapeutic Peptide Delivery: Fundamentals, Formulations, and Recent Advances
Recent advances in the field of peptide therapeutics have led to the design and synthesis of many promising peptides. However, research and...
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The evolution of commercial drug delivery technologies
Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a...
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Peptide permeation enhancers for improving oral bioavailability of macromolecules
BackgroundOral delivery of macromolecules has been limited mainly by their low intestinal permeability. Chemical permeation enhancers (CPEs) are...
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Identification of a Multi-Component Formulation for Intestinal Delivery of a GLP-1/Glucagon Co-agonist Peptide
PurposeOral delivery of therapeutic peptides has been challenging due to multiple physiological factors and physicochemical properties of peptides....
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A Critical Overview of the Biological Effects of Excipients (Part II): Scientific Considerations and Tools for Oral Product Development
It is now recognized that a number of excipients previously considered to be “inert” have the capacity to alter drug oral bioavailability through a...
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Hormones and Hormones Antagonists
Diabetes mellitus (DM) encompasses a group of metabolic disorders characterized by persistent elevation of blood sugar levels. This condition arises...
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A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects
Biotherapeutics are highly efficacious, but the pain and inconvenience of chronic injections lead to poor patient compliance and compromise effective...
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The Impact of the Priority Review Voucher on Research and Development for Tropical Diseases
BackgroundIn 2007, the priority review voucher (PRV) was implemented in the US to incentivize research and development (R&D) for tropical diseases....
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Formulation of Biologics Including Biopharmaceutical Considerations
This chapter describes the various issues a formulator of biologics faces when turning an active pharmaceutical ingredient (API) into a...
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Porous silicon and silica carriers for delivery of peptide therapeutics
Peptides have gained tremendous popularity as biological therapeutic agents in recent years due to their favourable specificity, diversity of...
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Mucus-penetrating and permeation enhancer albumin-based nanoparticles for oral delivery of macromolecules: Application to bevacizumab
The oral administration of therapeutic proteins copes with important challenges (mainly degradation and poor absorption) making their potential...
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Localised Delivery of Macromolecules to the Large Intestine: Translation to Clinical Trials
Oral administration of macromolecules aimed at systemic delivery has been at the forefront of pharmaceutical research for over 50 years. Yet, in...
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Therapeutic Potential of Semaglutide, a Newer GLP-1 Receptor Agonist, in Abating Obesity, Non-Alcoholic Steatohepatitis and Neurodegenerative diseases: A Narrative Review
IntroductionSemaglutide, a peptidic GLP-1 receptor agonist, has been clinically approved for treatment of type 2 diabetes mellitus and is available...
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Bioanalytical Methods and Strategic Perspectives Addressing the Rising Complexity of Novel Bioconjugates and Delivery Routes for Biotherapeutics
In recent years, an increase in the discovery and development of biotherapeutics employing new modalities, such as bioconjugates or novel routes of...
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Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide
PurposeSuccessful oral peptide delivery faces two major hurdles: low enzymatic stability in the gastro-intestinal lumen and poor intestinal membrane...
