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Transcription
Transcription plays an essential role in producing protein-coding messenger RNAs (mRNAs) and also other noncoding RNAs essential for proper cell...
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Nascent transcription upon interferon-α2 stimulation on human and rhesus macaque lymphoblastoid cell lines
ObjectivesThe interferon-triggered innate immune response has been observed to be under strong diversifying selection to counteract the many...
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The homeobox transcription factor DUXBL controls exit from totipotency
In mice, exit from the totipotent two-cell (2C) stage embryo requires silencing of the 2C-associated transcriptional program. However, the molecular...
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The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes
Chromatin accessibility is a hallmark of active transcription and entails ATP-dependent nucleosome remodeling, which is carried out by complexes such...
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Internal initiation of reverse transcription in a Penelope-like retrotransposon
Eukaryotic retroelements are generally divided into two classes: long terminal repeat (LTR) retrotransposons and non-LTR retrotransposons. A third...
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Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications
BackgroundPancreatic ductal adenocarcinoma (PDAC) tends to undergo distant metastasis, especially liver metastasis, leading to a poor prognosis....
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LINE-1 transcription activates long-range gene expression
Long interspersed nuclear element-1 (LINE-1 or L1) is a retrotransposon group that constitutes 17% of the human genome and shows variable expression...
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From voice to ink (Vink): development and assessment of an automated, free-of-charge transcription tool
BackgroundVerbatim transcription of qualitative audio data is a cornerstone of analytic quality and rigor, yet the time and energy required for such...
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The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require strict control of effector...
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Multiomic profiling of transcription factor binding and function in human brain
Transcription factors (TFs) orchestrate gene expression programs crucial for brain function, but we lack detailed information about TF binding in...
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Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription
Eukaryotic transcription factors (TFs) activate gene expression by recruiting cofactors to promoters. However, the relationships between TFs,...
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Genetic architecture and correlations between the gut microbiome and gut gene transcription in Chinook salmon (Oncorhynchus tshawytscha)
Population divergence through selection can drive local adaptation in natural populations which has implications for the effective restoration of...
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Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis
Germinal center (GC) B cells undergo proliferation at very high rates in a hypoxic microenvironment but the cellular processes driving this are...
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Characterizing Candida glabrata Pdr1, a Hyperactive Transcription Factor Involved in Azole Resistance
This chapter illustrates how to prepare isogenic strains carrying gain-of-function forms of transcription factor Pdr1 in the human pathogen Candida...
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HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription
The fetal-to-adult switch in hemoglobin production is a model of developmental gene control with relevance to the treatment of hemoglobinopathies....
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Prediction of histone post-translational modification patterns based on nascent transcription data
The role of histone modifications in transcription remains incompletely understood. Here, we examine the relationship between histone modifications...
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Reverse transcription recombinase-aided amplification assay for avian influenza virus
Avian influenza virus (AIV) infection can lead to severe economic losses in the poultry industry and causes a serious risk for humans. A rapid and...
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Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway
Parkin ( PARK2 ) deficiency is frequently observed in various cancers and potentially promotes tumor progression. Here, we showed that Parkin...
