Search
Search Results
-
Bayesian belief network modelling approach for predicting and ranking risk factors for malaria infections among children under 5 years in refugee settlements in Uganda
BackgroundMalaria risk factors at household level are known to be complex, uncertain, stochastic, nonlinear, and multidimensional. The interplay...
-
Quality Risk Management
Patient safety is a growing and an ongoing concern across the pharmaceutical world. Implementing quality risk management (QRM) procedures throughout...
-
Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery
Pyrrolizidine alkaloids (PAs) occur as contaminants in plant-based foods and herbal medicines. Following metabolic activation by cytochrome P450...
-
A robust pipeline for ranking carrier frequencies of autosomal recessive and X-linked Mendelian disorders
Single gene disorders are individually rare but collectively common leading causes of neonatal and pediatric morbidity and mortality. Both parents or...
-
Computational optimization of antibody humanness and stability by systematic energy-based ranking
Conventional methods for humanizing animal-derived antibodies involve grafting their complementarity-determining regions onto homologous human...
-
Non-major bleeding risk of direct oral anticoagulants versus vitamin K antagonists for stroke prevention with atrial fibrillation: a systematic review and network meta-analysis
BackgroundDirect oral anticoagulants (DOACs) are associated with bleeding. Patients often stop taking DOACs due to non-major bleeding, which may lead...
-
Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification
BackgroundAlthough polygenic risk score (PRS) has emerged as a promising tool for predicting cancer risk from genome-wide association studies (GWAS),...
-
Pharmacology-based ranking of anti-cancer drugs to guide clinical development of cancer immunotherapy combinations
The success of antibodies targeting Programmed cell death protein 1 (PD-1) and its ligand L1 (PD-L1) in cancer treatment and the need for improving...
-
Risk Assessment and Risk-Benefit Assessment
The framework of risk analysis has become the principal procedure for dealing with food safety issues. Risk analysis consists of three components:...
-
Common genetic risk factors in ASD and ADHD co-occurring families
Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two major neurodevelopmental disorders that frequently...
-
An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study
BackgroundEarly-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients...
-
The prevalence and genotype distribution of high-risk human papillomaviruses among women in **anning, China
BackgroundThe persistent infection of high-risk Human papillomavirus(HPV) is considered the main cause of cervical intraepithelial neoplasia and...
-
Ranking and Rating Bicycle Helmet Safety Performance in Oblique Impacts Using Eight Different Brain Injury Models
Bicycle helmets are shown to offer protection against head injuries. Rating methods and test standards are used to evaluate different helmet designs...
-
High-resolution map** of age- and gender-specific risk of Clonorchis sinensis infection risk in Guangdong, China: a geostatistical modeling study
BackgroundThe latest national survey on the distribution of human parasites in China demonstrated that Guangdong was among the endemic provinces with...
-
A novel approach for personalized response model: deep learning with individual dropout feature ranking
Deep learning is the fastest growing field in artificial intelligence and has led to many transformative innovations in various domains. However,...
-
Family History and the Risk of Breast and Gastric Cancer
Epidemiologists have used family history, usually of first-degree relatives, as a marker for genetic risk, knowing that family history reflects the...
-
Associations between modifiable risk factors and hepatocellular carcinoma: a trans-ancestry Mendelian randomization study
BackgroundPotentially modifiable risk factors for hepatocellular carcinoma (HCC) have been investigated in observational epidemiology studies in East...
-
Evaluation of the clinical efficacy of vaginal treatment options for persistent high-risk human papillomavirus infection after excisional treatment of cervical high-grade squamous intraepithelial lesions: a systematic review and Bayesian network meta-analysis
BackgroundTo evaluate the clinical efficacy of different vaginal administration on cervical persistent high-risk human papillomavirus (HR-HPV)...
-
EEG Complexity Analysis of Brain States, Tasks and ASD Risk
Autism spectrum disorder is an increasingly prevalent and debilitating neurodevelopmental condition and an electroencephalogram (EEG) diagnostic...
-
Control Banding and the Global Rise of Qualitative Risk Assessment Strategies
Purpose of ReviewControl banding (CB) is a risk assessment strategy that has been applied globally to a variety of occupational hazards. This article...